TY - JOUR
T1 - Pancreatic cancer risk and ABO blood group alleles
T2 - Results from the Pancreatic Cancer Cohort Consortium
AU - Wolpin, Brian M.
AU - Kraft, Peter
AU - Gross, Myron
AU - Helzlsouer, Kathy
AU - Bueno-de-Mesquita, H. Bas
AU - Steplowski, Emily
AU - Stolzenberg-Solomon, Rachael Z.
AU - Arslan, Alan A.
AU - Jacobs, Eric J.
AU - LaCroix, Andrea
AU - Petersen, Gloria
AU - Zheng, Wei
AU - Albanes, Demetrius
AU - Allen, Naomi E.
AU - Amundadottir, Laufey
AU - Anderson, Garnet
AU - Boutron-Ruault, Marie Christine
AU - Buring, Julie E.
AU - Canzian, Federico
AU - Chanock, Stephen J.
AU - Clipp, Sandra
AU - Gaziano, John Michael
AU - Giovannucci, Edward L.
AU - Hallmans, Göran
AU - Hankinson, Susan E.
AU - Hoover, Robert N.
AU - Hunter, David J.
AU - Hutchinson, Amy
AU - Jacobs, Kevin
AU - Kooperberg, Charles
AU - Lynch, Shannon M.
AU - Mendelsohn, Julie B.
AU - Michaud, Dominique S.
AU - Overvad, Kim
AU - Patel, Alpa V.
AU - Rajkovic, Aleksandar
AU - Sanchéz, Maria José
AU - Shu, Xiao Ou
AU - Slimani, Nadia
AU - Thomas, Gilles
AU - Tobias, Geoffrey S.
AU - Trichopoulos, Dimitrios
AU - Vineis, Paolo
AU - Virtamo, Jarmo
AU - Wactawski-Wende, Jean
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne
AU - Fuchs, Patricia Hartge Charles S.
PY - 2010/2/1
Y1 - 2010/2/1
N2 - A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.
AB - A recent genome-wide association study (PanScan) identified significant associations at the ABO gene locus with risk of pancreatic cancer, but the influence of specific ABO genotypes remains unknown. We determined ABO genotypes (OO, AO, AA, AB, BO, and BB) in 1,534 cases and 1,583 controls from 12 prospective cohorts in PanScan, grouping participants by genotype-derived serologic blood type (O, A, AB, and B). Adjusted odds ratios (ORs) for pancreatic cancer by ABO alleles were calculated using logistic regression. Compared with blood type O, the ORs for pancreatic cancer in subjects with types A, AB, and B were 1.38 [95% confidence interval (95% CI), 1.18-1.62], 1.47 (95% CI, 1.07-2.02), and 1.53 (95% CI, 1.21-1.92), respectively. The incidence rates for blood types O, A, AB, and B were 28.9, 39.9, 41.8, and 44.5 cases per 100,000 subjects per year. An increase in risk was noted with the addition of each non-O allele. Compared with OO genotype, subjects with AO and AA genotype had ORs of 1.33 (95% CI, 1.13-1.58) and 1.61 (95% CI, 1.22-2.18), whereas subjects with BO and BB genotypes had ORs of 1.45 (95% CI, 1.14-1.85) and 2.42 (1.28-4.57). The population attributable fraction for non-O blood type was 19.5%. In a joint model with smoking, current smokers with non-O blood type had an adjusted OR of 2.68 (95% CI, 2.03-3.54) compared with nonsmokers of blood type O. We concluded that ABO genotypes were significantly associated with pancreatic cancer risk.
KW - ABO Blood-Group System/genetics
KW - Aged
KW - Alleles
KW - Cohort Studies
KW - Female
KW - Gene Frequency
KW - Genetic Predisposition to Disease
KW - Genotype
KW - Humans
KW - Logistic Models
KW - Male
KW - Middle Aged
KW - Odds Ratio
KW - Pancreatic Neoplasms/genetics
KW - Risk Factors
UR - http://www.scopus.com/inward/record.url?scp=76249122015&partnerID=8YFLogxK
U2 - 10.1158/0008-5472.CAN-09-2993
DO - 10.1158/0008-5472.CAN-09-2993
M3 - Article
C2 - 20103627
AN - SCOPUS:76249122015
SN - 0008-5472
VL - 70
SP - 1015
EP - 1023
JO - Cancer Research
JF - Cancer Research
IS - 3
ER -
