Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here?

Eileen S. Carpenter; Debora Barbosa Vendramini-Costa; Marie C. Hasselluhn; Anirban Maitra; Kenneth P. Olive; Edna Cukierman; Marina Pasca di Magliano; Mara H. Sherman

doi:10.1158/0008-5472.CAN-24-2860

Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here?

Eileen S. Carpenter
, Debora Barbosa Vendramini-Costa
, Marie C. Hasselluhn
, Anirban Maitra
, Kenneth P. Olive
, Edna Cukierman
, Marina Pasca di Magliano
, Mara H. Sherman

University of Michigan, Ann Arbor
Henry Ford Health System
Columbia University
University of Texas MD Anderson Cancer Center
Memorial Sloan-Kettering Cancer Center

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.

Original language	English
Pages (from-to)	3505-3508
Number of pages	4
Journal	Cancer Research
Volume	84
Issue number	21
Early online date	Sep 16 2024
DOIs	https://doi.org/10.1158/0008-5472.CAN-24-2860
State	Published - Nov 2024

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Animals
Cancer-Associated Fibroblasts/pathology
Carcinoma, Pancreatic Ductal/pathology
Humans
Pancreatic Neoplasms/pathology
Tumor Microenvironment

Access to Document

10.1158/0008-5472.CAN-24-2860

Cite this

@article{69d90620945842919ed58980433bc0df,

title = "Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here?",

abstract = "Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.",

keywords = "Animals, Cancer-Associated Fibroblasts/pathology, Carcinoma, Pancreatic Ductal/pathology, Humans, Pancreatic Neoplasms/pathology, Tumor Microenvironment",

author = "Carpenter, \{Eileen S.\} and Vendramini-Costa, \{Debora Barbosa\} and Hasselluhn, \{Marie C.\} and Anirban Maitra and Olive, \{Kenneth P.\} and Edna Cukierman and \{Pasca di Magliano\}, Marina and Sherman, \{Mara H.\}",

note = "{\textcopyright}2024 American Association for Cancer Research.",

year = "2024",

month = nov,

doi = "10.1158/0008-5472.CAN-24-2860",

language = "English",

volume = "84",

pages = "3505--3508",

journal = "Cancer Research",

issn = "0008-5472",

publisher = "American Association for Cancer Research Inc.",

number = "21",

}

TY - JOUR

T1 - Pancreatic Cancer–Associated Fibroblasts

T2 - Where Do We Go from Here?

AU - Carpenter, Eileen S.

AU - Vendramini-Costa, Debora Barbosa

AU - Hasselluhn, Marie C.

AU - Maitra, Anirban

AU - Olive, Kenneth P.

AU - Cukierman, Edna

AU - Pasca di Magliano, Marina

AU - Sherman, Mara H.

PY - 2024/11

Y1 - 2024/11

N2 - Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.

AB - Pancreatic ductal adenocarcinoma is a deadly disease and is projected to become the second leading cause of cancer-related death by 2030. A major hallmark is the exuberant host response comprising the tumor microenvironment, of which, cancer-associated fibroblasts (CAF) are a prevalent component. Despite the gains in understanding of their heterogeneity and functionality from CAF studies in recent years, there are many unanswered questions surrounding this diverse population of cells. Here, we summarize the views of several experts in the field, focusing on the current understanding of CAFs and challenges to address.

KW - Animals

KW - Cancer-Associated Fibroblasts/pathology

KW - Carcinoma, Pancreatic Ductal/pathology

KW - Humans

KW - Pancreatic Neoplasms/pathology

KW - Tumor Microenvironment

UR - https://www.scopus.com/pages/publications/85208513411

U2 - 10.1158/0008-5472.CAN-24-2860

DO - 10.1158/0008-5472.CAN-24-2860

M3 - Article

C2 - 39283867

SN - 0008-5472

VL - 84

SP - 3505

EP - 3508

JO - Cancer Research

JF - Cancer Research

IS - 21

ER -

Pancreatic Cancer–Associated Fibroblasts: Where Do We Go from Here?

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this