Pak GITs to Aurora-A

Sophie Cotteret, Jonathan Chernoff

Research output: Contribution to journalShort surveypeer-review

12 Scopus citations

Abstract

The protein kinase Aurora-A orchestrates key aspects of cell division, but its regulation has remained a major puzzle. That puzzle is now one step closer to being solved thanks to a recent paper by Zhao et al. appearing in the October 28th issue of Molecular Cell. In this work, the authors show that p21-activated kinases (Paks), previously best known for their role in cytoskeletal and transcriptional signaling pathways, also play an important role in centrosome dynamics via phosphorylation and activation of Aurora-A.

Original languageEnglish
Pages (from-to)573-574
Number of pages2
JournalDevelopmental Cell
Volume9
Issue number5
DOIs
StatePublished - Nov 2005

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