Paired papanicolaou smears in the evaluation of atypical squamous cells

Stephen Andrews, Enrique Hernandez, Kunio Miyazawa

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

Between February 1985 and April 1988, 360 women were seen at Tripler Army Medical Center’s cervical clinic as part of a prospective study to assess the value of paired Papanicolaou smears in the follow-up of atypical squamous cells in a cervical cytologic smear. The evaluation consisted of paired repeat Papanicolaou smears and colposcopy. Colposcopically directed biopsies and/or endocervical curettage were performed in 86% of the subjects. The results of the paired Papanicolaou smears were negative/negative in 202 patients (56%). Cervical intraepithelial neoplasia was diagnosed histopathologically in 16% of all patients and in 10% of those with negative/negative repeat smears. We conclude that the presence of atypical squamous cells in a Papanicolaou smear should be considered abnormal and that colposcopy and colposcopically directed biopsies should be performed for these patients.

Original languageEnglish
Pages (from-to)747-750
Number of pages4
JournalObstetrics and Gynecology
Volume73
Issue number5 Pt 1
StatePublished - May 1989

Keywords

  • Adolescent
  • Adult
  • Aged
  • Cervix Uteri/pathology
  • Colposcopy
  • Epithelium/pathology
  • False Negative Reactions
  • Female
  • Humans
  • Middle Aged
  • Papanicolaou Test
  • Prospective Studies
  • Uterine Cervical Neoplasms/pathology
  • Vaginal Smears

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