p53 regulates the mitochondrial immune checkpoint

Claire Vanpouille-Box, Lorenzo Galluzzi

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing.

Original languageEnglish
Pages (from-to)245-247
Number of pages3
JournalTrends in Immunology
Volume44
Issue number4
DOIs
StatePublished - Apr 2023
Externally publishedYes

Keywords

  • Apoptosis
  • DNA, Mitochondrial/genetics
  • Humans
  • Mitochondria/metabolism
  • Tumor Suppressor Protein p53/genetics

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