TY - JOUR
T1 - p21-Activated kinases
T2 - Three more join the Pak
AU - Jaffer, Zahara M.
AU - Chernoff, Jonathan
PY - 2002
Y1 - 2002
N2 - The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into two subgroups based on architectural similarities. The Group I Paks (Pak1, Pak2, Pak3) have been studied in greater detail and shown to be involved in the regulation of cellular processes such as gene transcription, cell morphology, motility, and apoptosis. Here we summarize recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) and review both similarities and differences between kinases of the two Pak subgroups.
AB - The p21-activated kinases (Paks) are serine/threonine protein kinases that bind to and, in some cases, are stimulated by activated forms of the small GTPases, Cdc42 and Rac. With the recent discovery of several novel isoforms, Paks are now categorized into two subgroups based on architectural similarities. The Group I Paks (Pak1, Pak2, Pak3) have been studied in greater detail and shown to be involved in the regulation of cellular processes such as gene transcription, cell morphology, motility, and apoptosis. Here we summarize recent findings that shed light on the newly recognized Group II Paks (Pak4, Pak5, Pak6) and review both similarities and differences between kinases of the two Pak subgroups.
KW - Animals
KW - Apoptosis/physiology
KW - Binding Sites
KW - Cell Transformation, Neoplastic
KW - Cytoskeleton/enzymology
KW - Humans
KW - Models, Biological
KW - Molecular Structure
KW - Protein Serine-Threonine Kinases/chemistry
KW - Receptors, Androgen/metabolism
KW - Signal Transduction
KW - p21-Activated Kinases
UR - http://www.scopus.com/inward/record.url?scp=0036223236&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000176012900001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/S1357-2725(01)00158-3
DO - 10.1016/S1357-2725(01)00158-3
M3 - Short survey
C2 - 11950587
SN - 1357-2725
VL - 34
SP - 713
EP - 717
JO - International Journal of Biochemistry and Cell Biology
JF - International Journal of Biochemistry and Cell Biology
IS - 7
ER -