TY - JOUR
T1 - Oxaliplatin-induced Immune Thrombocytopenia
T2 - A Case Report and Literature Review
AU - Stack, Anthony
AU - Khanal, Rashmi
AU - Denlinger, Crystal S.
PY - 2021/3
Y1 - 2021/3
N2 - Oxaliplatin-induced immune thrombocytopenia is a rare manifestation of oxaliplatin hypersensitivity, presenting as an acute onset of severe thrombocytopenia after oxaliplatin administration. No standard therapeutic approach outside of permanent discontinuation of oxaliplatin exists. Here, we present a case of oxaliplatin-induced immune thrombocytopenia occurring after oxaliplatin retreatment for metastatic colon cancer. Possible mechanisms of disease and approach to treatment are discussed.
AB - Oxaliplatin-induced immune thrombocytopenia is a rare manifestation of oxaliplatin hypersensitivity, presenting as an acute onset of severe thrombocytopenia after oxaliplatin administration. No standard therapeutic approach outside of permanent discontinuation of oxaliplatin exists. Here, we present a case of oxaliplatin-induced immune thrombocytopenia occurring after oxaliplatin retreatment for metastatic colon cancer. Possible mechanisms of disease and approach to treatment are discussed.
KW - Antineoplastic Combined Chemotherapy Protocols/adverse effects
KW - Chemotherapy, Adjuvant/adverse effects
KW - Colectomy
KW - Colorectal Neoplasms/blood
KW - Female
KW - Fluorouracil/adverse effects
KW - Humans
KW - Leucovorin/adverse effects
KW - Middle Aged
KW - Organoplatinum Compounds/adverse effects
KW - Oxaliplatin/adverse effects
KW - Thrombocytopenia/blood
UR - http://www.scopus.com/inward/record.url?scp=85092204681&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000647374800001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1016/j.clcc.2020.07.007
DO - 10.1016/j.clcc.2020.07.007
M3 - Article
C2 - 33012678
SN - 1533-0028
VL - 20
SP - e1-e4
JO - Clinical Colorectal Cancer
JF - Clinical Colorectal Cancer
IS - 1
ER -
