TY - JOUR
T1 - Outcomes and predictors of benign histology in patients undergoing robotic partial or radical nephrectomy for renal masses
T2 - A multicenter study
AU - Nandanan, Naveen
AU - Veccia, Alessandro
AU - Antonelli, Alessandro
AU - Derweesh, Ithaar
AU - Mottrie, Alexandre
AU - Minervini, Andrea
AU - Aron, Monish
AU - Simone, Giuseppe
AU - Capitanio, Umberto
AU - Simeone, Claudio
AU - Eun, Daniel
AU - Perdonà, Sisto
AU - Porter, James
AU - Sundaram, Chandru
AU - Zhang, Chao
AU - Uzzo, Robert
AU - Challacombe, Ben
AU - Hampton, Lance J.
AU - Kaouk, Jihad
AU - Porpiglia, Francesco
AU - Autorino, Riccardo
N1 - Publisher Copyright:
© 2020, Polish Urological Association. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Introduction Theaim of this study was to assess preoperative factors associated with benign histology in patients undergoing surgical removal of a renal mass and to analyze outcomes of robotic partial nephrectomy (PN) and radical nephrectomy (RN) for these masses. Material and methods Overall, 2,944 cases (543 benign and 2,401 malignant) who underwent robotic PN and RN between 2003–2018 at 10 institutions worldwide were included. The assessment of the predictors of benign histology was made at the final surgical pathology report. Descriptive statistics, Mann-Whitney U, Pearson’s χ2, and logistic regression analysis were used. Results Patients in the benign group were mostly female (61 vs. 33%; p <0.001), with lower body mass index (BMI) (26.0 vs. 27.1 kg/m2; p <0.001). The benign group presented smaller tumor size (2.8 vs. 3.5 cm; p <0.001), R.E.N.A.L. score (6.0 vs. 7.0; p <0.001). There was a lower rate of hilar (11 vs.18%; p = 0.001), cT≥3 (1 vs. 4.5%; p <0.001) tumors in the benign group. There was a statistically significant higher rate of PN in the benign group (97 vs. 86%; p <0.001) as well as a statistically significant lower 30-day re-admission rate (2 vs. 5%; p = 0.081). Multivariable analysis showed male gender (OR: 0.52; p <0.001), BMI (OR: 0.95; p <0.001), and cT3a (OR: 0.22; p = 0.005) to be inversely associated to benign histology. Conclusions In 18% of cases, a benign histologic type was found. Only 3% of these tumors were treated with RN. Female gender, lower BMI, and higher T staging showed to be independent predictors of benign histology.
AB - Introduction Theaim of this study was to assess preoperative factors associated with benign histology in patients undergoing surgical removal of a renal mass and to analyze outcomes of robotic partial nephrectomy (PN) and radical nephrectomy (RN) for these masses. Material and methods Overall, 2,944 cases (543 benign and 2,401 malignant) who underwent robotic PN and RN between 2003–2018 at 10 institutions worldwide were included. The assessment of the predictors of benign histology was made at the final surgical pathology report. Descriptive statistics, Mann-Whitney U, Pearson’s χ2, and logistic regression analysis were used. Results Patients in the benign group were mostly female (61 vs. 33%; p <0.001), with lower body mass index (BMI) (26.0 vs. 27.1 kg/m2; p <0.001). The benign group presented smaller tumor size (2.8 vs. 3.5 cm; p <0.001), R.E.N.A.L. score (6.0 vs. 7.0; p <0.001). There was a lower rate of hilar (11 vs.18%; p = 0.001), cT≥3 (1 vs. 4.5%; p <0.001) tumors in the benign group. There was a statistically significant higher rate of PN in the benign group (97 vs. 86%; p <0.001) as well as a statistically significant lower 30-day re-admission rate (2 vs. 5%; p = 0.081). Multivariable analysis showed male gender (OR: 0.52; p <0.001), BMI (OR: 0.95; p <0.001), and cT3a (OR: 0.22; p = 0.005) to be inversely associated to benign histology. Conclusions In 18% of cases, a benign histologic type was found. Only 3% of these tumors were treated with RN. Female gender, lower BMI, and higher T staging showed to be independent predictors of benign histology.
KW - Benign renal masses
KW - Malignant renal masses
KW - Predictors
KW - Renal cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=85083782882&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000548179400004&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.5173/ceju.2020.0019
DO - 10.5173/ceju.2020.0019
M3 - Article
C2 - 32395320
SN - 2080-4806
VL - 73
SP - 33
EP - 38
JO - Central European Journal of Urology
JF - Central European Journal of Urology
IS - 1
ER -