Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia

Harry B. Koo; Elin R. Sigurdson; John M. Daly; Mark Berenson; Susan Groshen; Jerome J. Decosse

doi:10.1002/jso.2930380407

Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia

Harry B. Koo, Elin R. Sigurdson, John M. Daly, Mark Berenson, Susan Groshen, Jerome J. Decosse

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.

Original language	English
Pages (from-to)	240-243
Number of pages	4
Journal	Journal of Surgical Oncology
Volume	38
Issue number	4
DOIs	https://doi.org/10.1002/jso.2930380407
State	Published - Aug 1988

Keywords

Adenoma/enzymology
Adult
Aged
Biomarkers, Tumor/analysis
Colonic Neoplasms/enzymology
Female
Humans
Intestinal Mucosa/enzymology
Male
Middle Aged
Ornithine Decarboxylase/analysis
Rectum/enzymology
Sex Characteristics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/jso.2930380407

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title = "Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia",

abstract = "Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.",

keywords = "Adenoma/enzymology, Adult, Aged, Biomarkers, Tumor/analysis, Colonic Neoplasms/enzymology, Female, Humans, Intestinal Mucosa/enzymology, Male, Middle Aged, Ornithine Decarboxylase/analysis, Rectum/enzymology, Sex Characteristics",

author = "Koo, {Harry B.} and Sigurdson, {Elin R.} and Daly, {John M.} and Mark Berenson and Susan Groshen and Decosse, {Jerome J.}",

year = "1988",

month = aug,

doi = "10.1002/jso.2930380407",

language = "English",

volume = "38",

pages = "240--243",

journal = "Journal of Surgical Oncology",

issn = "0022-4790",

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T1 - Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia

AU - Koo, Harry B.

AU - Sigurdson, Elin R.

AU - Daly, John M.

AU - Berenson, Mark

AU - Groshen, Susan

AU - Decosse, Jerome J.

PY - 1988/8

Y1 - 1988/8

N2 - Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.

AB - Ornithine decarboxylase (ODC) activity in biopsy specimens of normalappearing rectal mucosa was measured in 15 control patients, 5 patients with colon adenomas, and 11 patients with colon cancer. While women had significantly higher ODC activity than men, ODC activity was increased regardless of gender in the rectal mucosal biopsies of patients with benign or malignant colonic neoplasia compared with those of controls. The positive predictive value of ODC activity for remote colonic neoplasia was 61 % for women and 91 % for men. The results provide a rationale for long‐term studies of ODC activity in rectal mucosa as a biological marker of high risk for large bowel neoplasia.

KW - Adenoma/enzymology

KW - Adult

KW - Aged

KW - Biomarkers, Tumor/analysis

KW - Colonic Neoplasms/enzymology

KW - Female

KW - Humans

KW - Intestinal Mucosa/enzymology

KW - Male

KW - Middle Aged

KW - Ornithine Decarboxylase/analysis

KW - Rectum/enzymology

KW - Sex Characteristics

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U2 - 10.1002/jso.2930380407

DO - 10.1002/jso.2930380407

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AN - SCOPUS:0023754991

SN - 0022-4790

VL - 38

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JO - Journal of Surgical Oncology

JF - Journal of Surgical Oncology

IS - 4

ER -

Ornithine decarboxylase levels in the rectal mucosa of patients with colonic neoplasia

Abstract

Keywords

UN SDGs

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