TY - JOUR
T1 - Optimization strategies for pulsed low-dose-rate IMRT of recurrent lung and head and neck cancers
AU - Kang, Shengwei
AU - Lang, Jinyi
AU - Wang, Pei
AU - Li, Jie
AU - Lin, Muhan
AU - Chen, Xiaoming
AU - Guo, Ming
AU - Chen, Fu
AU - Chen, Lili
AU - Ma, Chang Ming
PY - 2014
Y1 - 2014
N2 - Pulsed low-dose-rate radiotherapy (PLDR) has been proven to be a valid method of reirradiation. Previous studies of recurrent cancer radiotherapy were mainly based on conventional 3D CRT and VMAT delivery techniques. There are difficulties in IMRT planning using existing commercial treatment planning systems (TPS) to meet the PLDR protocol. This work focuses on PLDR using ten-field IMRT and a commercial TPS for two specific sites: recurrent lung cancers and head and neck cancers. Our PLDR protocol requires that the maximum dose to the PTV be less than 0.4 Gy and the mean dose to be 0.2 Gy per field. We investigated various planning strategies to meet the PLDR requirements for 20 lung and head and neck patients. The PTV volume for lung cases ranged from 101.7 to 919.4 cm3 and the maximum dose to the PTV ranged from 0.22 to 0.39 Gy. The PTV volume for head and neck cases ranged from 66.2 to 282.1 cm3 and the maximum dose to the PTV ranged from 0.21 to 0.39 Gy. With special beam arrangements and dosimetry parameters, it is feasible to use a commercial TPS to generate quality PLDR IMRT plans for lung and head and neck reirradiation.
AB - Pulsed low-dose-rate radiotherapy (PLDR) has been proven to be a valid method of reirradiation. Previous studies of recurrent cancer radiotherapy were mainly based on conventional 3D CRT and VMAT delivery techniques. There are difficulties in IMRT planning using existing commercial treatment planning systems (TPS) to meet the PLDR protocol. This work focuses on PLDR using ten-field IMRT and a commercial TPS for two specific sites: recurrent lung cancers and head and neck cancers. Our PLDR protocol requires that the maximum dose to the PTV be less than 0.4 Gy and the mean dose to be 0.2 Gy per field. We investigated various planning strategies to meet the PLDR requirements for 20 lung and head and neck patients. The PTV volume for lung cases ranged from 101.7 to 919.4 cm3 and the maximum dose to the PTV ranged from 0.22 to 0.39 Gy. The PTV volume for head and neck cases ranged from 66.2 to 282.1 cm3 and the maximum dose to the PTV ranged from 0.21 to 0.39 Gy. With special beam arrangements and dosimetry parameters, it is feasible to use a commercial TPS to generate quality PLDR IMRT plans for lung and head and neck reirradiation.
KW - H&N cancer
KW - IMRT
KW - Lung cancer
KW - Pulsed low-dose-rate radiotherapy (PLDR)
KW - Recurrent cancer
KW - Reproducibility of Results
KW - Radiotherapy Planning, Computer-Assisted/methods
KW - Neoplasm Recurrence, Local/radiotherapy
KW - Radiotherapy, Intensity-Modulated/methods
KW - Humans
KW - Lung Neoplasms/radiotherapy
KW - Treatment Outcome
KW - Head and Neck Neoplasms/radiotherapy
KW - Dose Fractionation, Radiation
KW - Sensitivity and Specificity
KW - Retrospective Studies
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UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000336044300012&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1120/jacmp.v15i3.4661
DO - 10.1120/jacmp.v15i3.4661
M3 - Article
C2 - 24892337
SN - 1526-9914
VL - 15
SP - 102
EP - 113
JO - Journal of Applied Clinical Medical Physics
JF - Journal of Applied Clinical Medical Physics
IS - 3
ER -
