Oncogenic tyrosine kinases and the DNA-damage response

Tomasz Skorski

doi:10.1038/nrc799

Oncogenic tyrosine kinases and the DNA-damage response

Tomasz Skorski

Temple University

Research output: Contribution to journal › Review article › peer-review

118 Scopus citations

Abstract

Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?

Original language	English
Pages (from-to)	351-360
Number of pages	10
Journal	Nature Reviews Cancer
Volume	2
Issue number	5
DOIs	https://doi.org/10.1038/nrc799
State	Published - May 2002

Keywords

Apoptosis
DNA Damage
DNA, Neoplasm/metabolism
Humans
Neoplasms/metabolism
Protein-Tyrosine Kinases/physiology
Proto-Oncogene Proteins/physiology
Ultraviolet Rays

Access to Document

10.1038/nrc799

Cite this

@article{ae1d61e919534d87bea7757d67d22c0e,

title = "Oncogenic tyrosine kinases and the DNA-damage response",

abstract = "Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?",

keywords = "Apoptosis, DNA Damage, DNA, Neoplasm/metabolism, Humans, Neoplasms/metabolism, Protein-Tyrosine Kinases/physiology, Proto-Oncogene Proteins/physiology, Ultraviolet Rays",

author = "Tomasz Skorski",

year = "2002",

month = may,

doi = "10.1038/nrc799",

language = "English",

volume = "2",

pages = "351--360",

journal = "Nature Reviews Cancer",

issn = "1474-175X",

publisher = "Nature Publishing Group",

number = "5",

}

TY - JOUR

T1 - Oncogenic tyrosine kinases and the DNA-damage response

AU - Skorski, Tomasz

PY - 2002/5

Y1 - 2002/5

N2 - Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?

AB - Oncogenic tyrosine kinases (OTKs) are involved in the induction of many types of tumour, including haematological malignancies and cancers of the breast, prostate, colon and lung. Neoplastic cells that express OTKs are usually resistant to apoptosis that is induced by DNA-damaging agents, such as cytostatic drugs and irradiation, and they display genomic instability. So, what are the mechanisms involved, and what is the potential for overcoming OTK-mediated resistance in the clinic?

KW - Apoptosis

KW - DNA Damage

KW - DNA, Neoplasm/metabolism

KW - Humans

KW - Neoplasms/metabolism

KW - Protein-Tyrosine Kinases/physiology

KW - Proto-Oncogene Proteins/physiology

KW - Ultraviolet Rays

UR - http://www.scopus.com/inward/record.url?scp=0036560577&partnerID=8YFLogxK

U2 - 10.1038/nrc799

DO - 10.1038/nrc799

M3 - Review article

C2 - 12044011

SN - 1474-175X

VL - 2

SP - 351

EP - 360

JO - Nature Reviews Cancer

JF - Nature Reviews Cancer

IS - 5

ER -

Oncogenic tyrosine kinases and the DNA-damage response

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this