Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma

Yichi Zhang; Marjaana Ojalill; Antonia Boyer; Xiao Lei Chen; Elise Tahon; Gaëtan Thivolle Lioux; Marvin Xia; Maryam Abbas; Halime Meryem Soylu; Douglas B Flieder; Denise C Connolly; Alfredo A Molinolo; Michael T McHale; Dwayne G Stupack; David D Schlaepfer

doi:10.1158/2767-9764.CRC-24-0382

Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma

Yichi Zhang, Marjaana Ojalill, Antonia Boyer, Xiao Lei Chen, Elise Tahon, Gaëtan Thivolle Lioux, Marvin Xia, Maryam Abbas, Halime Meryem Soylu, Douglas B Flieder, Denise C Connolly, Alfredo A Molinolo, Michael T McHale, Dwayne G Stupack, David D Schlaepfer

Research output: Contribution to journal › Article › peer-review

Abstract

FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.

Original language	English
Pages (from-to)	3165-3179
Number of pages	15
Journal	Cancer Research Communications
Volume	4
Issue number	12
Early online date	Nov 25 2024
DOIs	https://doi.org/10.1158/2767-9764.CRC-24-0382 https://doi.org/10.1158/2767-9764.CRC-24-0382
State	Published - Dec 1 2024

Keywords

Antineoplastic Agents/pharmacology
Cell Line, Tumor
Cell Nucleus/drug effects
Cell Survival/drug effects
Cisplatin/pharmacology
Female
Focal Adhesion Kinase 1/metabolism
Focal Adhesion Protein-Tyrosine Kinases/metabolism
Humans
MAP Kinase Signaling System/drug effects
Ovarian Neoplasms/drug therapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

Cite this

Zhang, Y., Ojalill, M., Boyer, A., Chen, X. L., Tahon, E., Thivolle Lioux, G., Xia, M., Abbas, M., Soylu, H. M., Flieder, D. B., Connolly, D. C., Molinolo, A. A., McHale, M. T., Stupack, D. G., & Schlaepfer, D. D. (2024). Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma. Cancer Research Communications, 4(12), 3165-3179. https://doi.org/10.1158/2767-9764.CRC-24-0382, https://doi.org/10.1158/2767-9764.CRC-24-0382

@article{292a9a375ea043068c9243f98b0901e1,

title = "Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma",

abstract = "FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.",

keywords = "Antineoplastic Agents/pharmacology, Cell Line, Tumor, Cell Nucleus/drug effects, Cell Survival/drug effects, Cisplatin/pharmacology, Female, Focal Adhesion Kinase 1/metabolism, Focal Adhesion Protein-Tyrosine Kinases/metabolism, Humans, MAP Kinase Signaling System/drug effects, Ovarian Neoplasms/drug therapy",

author = "Yichi Zhang and Marjaana Ojalill and Antonia Boyer and Chen, {Xiao Lei} and Elise Tahon and {Thivolle Lioux}, Ga{\"e}tan and Marvin Xia and Maryam Abbas and Soylu, {Halime Meryem} and Flieder, {Douglas B} and Connolly, {Denise C} and Molinolo, {Alfredo A} and McHale, {Michael T} and Stupack, {Dwayne G} and Schlaepfer, {David D}",

note = "{\textcopyright}2024 The Authors; Published by the American Association for Cancer Research.",

year = "2024",

month = dec,

day = "1",

doi = "10.1158/2767-9764.CRC-24-0382",

language = "English",

volume = "4",

pages = "3165--3179",

journal = "Cancer Research Communications",

issn = "2767-9764",

publisher = "American Association for Cancer Research Inc.",

number = "12",

}

Zhang, Y, Ojalill, M, Boyer, A, Chen, XL, Tahon, E, Thivolle Lioux, G, Xia, M, Abbas, M, Soylu, HM, Flieder, DB , Connolly, DC, Molinolo, AA, McHale, MT, Stupack, DG & Schlaepfer, DD 2024, 'Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma', Cancer Research Communications, vol. 4, no. 12, pp. 3165-3179. https://doi.org/10.1158/2767-9764.CRC-24-0382, https://doi.org/10.1158/2767-9764.CRC-24-0382

TY - JOUR

T1 - Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma

AU - Zhang, Yichi

AU - Ojalill, Marjaana

AU - Boyer, Antonia

AU - Chen, Xiao Lei

AU - Tahon, Elise

AU - Thivolle Lioux, Gaëtan

AU - Xia, Marvin

AU - Abbas, Maryam

AU - Soylu, Halime Meryem

AU - Flieder, Douglas B

AU - Connolly, Denise C

AU - Molinolo, Alfredo A

AU - McHale, Michael T

AU - Stupack, Dwayne G

AU - Schlaepfer, David D

PY - 2024/12/1

Y1 - 2024/12/1

N2 - FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.

AB - FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.

KW - Antineoplastic Agents/pharmacology

KW - Cell Line, Tumor

KW - Cell Nucleus/drug effects

KW - Cell Survival/drug effects

KW - Cisplatin/pharmacology

KW - Female

KW - Focal Adhesion Kinase 1/metabolism

KW - Focal Adhesion Protein-Tyrosine Kinases/metabolism

KW - Humans

KW - MAP Kinase Signaling System/drug effects

KW - Ovarian Neoplasms/drug therapy

UR - http://www.scopus.com/inward/record.url?scp=85213597014&partnerID=8YFLogxK

U2 - 10.1158/2767-9764.CRC-24-0382

DO - 10.1158/2767-9764.CRC-24-0382

M3 - Article

C2 - 39585085

SN - 2767-9764

VL - 4

SP - 3165

EP - 3179

JO - Cancer Research Communications

JF - Cancer Research Communications

IS - 12

ER -

Nuclear Focal Adhesion Kinase Protects Against Cisplatin Stress in Ovarian Carcinoma

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this