Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma

Shuanzeng Wei; Jianming Pei; Paul Belser; Teresa Lee; Jeffrey M. Farma; Arthur S. Patchefsky; Douglas B. Flieder; Elizabeth A. Montgomery

doi:10.1002/gcc.23239

Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma

Shuanzeng Wei, Jianming Pei, Paul Belser, Teresa Lee, Jeffrey M. Farma, Arthur S. Patchefsky, Douglas B. Flieder, Elizabeth A. Montgomery

Research output: Contribution to journal › Article › peer-review

Abstract

Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1::PLAG1, RAD51B::PLAG1, and TRIM13::PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HG::PLAG1 fusion detected by RNA next-generation sequencing.

Original language	English
Article number	e23239
Journal	Genes Chromosomes and Cancer
Volume	63
Issue number	4
DOIs	https://doi.org/10.1002/gcc.23239
State	Published - Mar 2024

Keywords

MIR143HG::PLAG1
myxoid leiomyosarcoma
next generation sequencing
translocation
Leiomyosarcoma/genetics
MicroRNAs/genetics
DNA-Binding Proteins/genetics
Humans
Middle Aged
Female
Rectal Neoplasms/genetics
Oncogene Proteins, Fusion/genetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/gcc.23239

Cite this

@article{9ee4093dffe746eabb1b9f1a0a1f710d,

title = "Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma",

abstract = "Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1::PLAG1, RAD51B::PLAG1, and TRIM13::PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HG::PLAG1 fusion detected by RNA next-generation sequencing.",

keywords = "MIR143HG::PLAG1, myxoid leiomyosarcoma, next generation sequencing, translocation, Leiomyosarcoma/genetics, MicroRNAs/genetics, DNA-Binding Proteins/genetics, Humans, Middle Aged, Female, Rectal Neoplasms/genetics, Oncogene Proteins, Fusion/genetics",

author = "Shuanzeng Wei and Jianming Pei and Paul Belser and Teresa Lee and Farma, {Jeffrey M.} and Patchefsky, {Arthur S.} and Flieder, {Douglas B.} and Montgomery, {Elizabeth A.}",

note = "Publisher Copyright: {\textcopyright} 2024 Wiley Periodicals LLC.",

year = "2024",

month = mar,

doi = "10.1002/gcc.23239",

language = "English",

volume = "63",

journal = "Genes Chromosomes and Cancer",

issn = "1045-2257",

publisher = "Wiley-Liss Inc.",

number = "4",

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TY - JOUR

T1 - Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma

AU - Wei, Shuanzeng

AU - Pei, Jianming

AU - Belser, Paul

AU - Lee, Teresa

AU - Farma, Jeffrey M.

AU - Patchefsky, Arthur S.

AU - Flieder, Douglas B.

AU - Montgomery, Elizabeth A.

PY - 2024/3

Y1 - 2024/3

N2 - Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1::PLAG1, RAD51B::PLAG1, and TRIM13::PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HG::PLAG1 fusion detected by RNA next-generation sequencing.

AB - Myxoid leiomyosarcoma (MLS) is a rare but well-documented tumor that often portends a poor prognosis compared to the conventional leiomyosarcoma. This rare sarcoma has been reported in the uterus, external female genitalia, soft tissue, and other locations. However, a definite rectal MLS has not been reported. Recently five cases of MLS were reported to harbor PLAG1 fusions (TRPS1::PLAG1, RAD51B::PLAG1, and TRIM13::PLAG1). In this report, we present a case of rectal MLS with a novel MIR143HG::PLAG1 fusion detected by RNA next-generation sequencing.

KW - MIR143HG::PLAG1

KW - myxoid leiomyosarcoma

KW - next generation sequencing

KW - translocation

KW - Leiomyosarcoma/genetics

KW - MicroRNAs/genetics

KW - DNA-Binding Proteins/genetics

KW - Humans

KW - Middle Aged

KW - Female

KW - Rectal Neoplasms/genetics

KW - Oncogene Proteins, Fusion/genetics

UR - http://www.scopus.com/inward/record.url?scp=85191158866&partnerID=8YFLogxK

U2 - 10.1002/gcc.23239

DO - 10.1002/gcc.23239

M3 - Article

C2 - 38656544

AN - SCOPUS:85191158866

SN - 1045-2257

VL - 63

JO - Genes Chromosomes and Cancer

JF - Genes Chromosomes and Cancer

IS - 4

M1 - e23239

ER -

Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma

Abstract

Keywords

UN SDGs

Access to Document

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Findings from Fox Chase Cancer Center Reveals New Findings on Leiomyosarcoma (Novel mir143hg::plag1 Gene Fusion Identified In a Rectal Myxoid Leiomyosarcoma)

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Novel MIR143HG::PLAG1 gene fusion identified in a rectal myxoid leiomyosarcoma

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Press/Media

Findings from Fox Chase Cancer Center Reveals New Findings on Leiomyosarcoma (Novel mir143hg::plag1 Gene Fusion Identified In a Rectal Myxoid Leiomyosarcoma)

Cite this