Novel Insights into PML-Dependent Oncosuppression

Lorenzo Galluzzi

doi:10.1016/j.tcb.2016.09.001

Novel Insights into PML-Dependent Oncosuppression

Lorenzo Galluzzi

Research output: Contribution to journal › Short survey › peer-review

6 Scopus citations

Abstract

At odds with its nuclear counterpart, extranuclear promyelocytic leukemia constitutively inhibits autophagy, hence limiting cancer progression. These data raise the interesting possibility that some tumor suppressors have become specialized to operate at multiple subcellular compartments for counteracting different aspects of the oncogenic process.

Original language	English
Pages (from-to)	889-890
Number of pages	2
Journal	Trends in Cell Biology
Volume	26
Issue number	12
DOIs	https://doi.org/10.1016/j.tcb.2016.09.001
State	Published - Dec 1 2016
Externally published	Yes

Keywords

autophagy
beclin 1
chloroquine
MAMs
p53
regulated cell death

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tcb.2016.09.001

Cite this

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title = "Novel Insights into PML-Dependent Oncosuppression",

abstract = "At odds with its nuclear counterpart, extranuclear promyelocytic leukemia constitutively inhibits autophagy, hence limiting cancer progression. These data raise the interesting possibility that some tumor suppressors have become specialized to operate at multiple subcellular compartments for counteracting different aspects of the oncogenic process.",

keywords = "autophagy, beclin 1, chloroquine, MAMs, p53, regulated cell death",

author = "Lorenzo Galluzzi",

note = "Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

month = dec,

day = "1",

doi = "10.1016/j.tcb.2016.09.001",

language = "English",

volume = "26",

pages = "889--890",

journal = "Trends in Cell Biology",

issn = "0962-8924",

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number = "12",

}

TY - JOUR

T1 - Novel Insights into PML-Dependent Oncosuppression

AU - Galluzzi, Lorenzo

PY - 2016/12/1

Y1 - 2016/12/1

N2 - At odds with its nuclear counterpart, extranuclear promyelocytic leukemia constitutively inhibits autophagy, hence limiting cancer progression. These data raise the interesting possibility that some tumor suppressors have become specialized to operate at multiple subcellular compartments for counteracting different aspects of the oncogenic process.

AB - At odds with its nuclear counterpart, extranuclear promyelocytic leukemia constitutively inhibits autophagy, hence limiting cancer progression. These data raise the interesting possibility that some tumor suppressors have become specialized to operate at multiple subcellular compartments for counteracting different aspects of the oncogenic process.

KW - autophagy

KW - beclin 1

KW - chloroquine

KW - MAMs

KW - p53

KW - regulated cell death

UR - http://www.scopus.com/inward/record.url?scp=84994717988&partnerID=8YFLogxK

U2 - 10.1016/j.tcb.2016.09.001

DO - 10.1016/j.tcb.2016.09.001

M3 - Short survey

C2 - 27663133

AN - SCOPUS:84994717988

SN - 0962-8924

VL - 26

SP - 889

EP - 890

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 12

ER -

Novel Insights into PML-Dependent Oncosuppression

Abstract

Keywords

UN SDGs

Access to Document

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