76 Scopus citations

Abstract

Bcl-2 proteins are widely known as key controllers of mitochondrial outer membrane permeabilization, arguably the most important step of intrinsic apoptosis. Accumulating evidence indicate that most, if not all, members of the Bcl-2 protein family also mediate a number of apoptosis-unrelated functions. Intriguingly, many of these functions ultimately impinge on cell fate decisions via apoptosis-dependent or -independent mechanisms, delineating a complex network through which Bcl-2 family members regulate cell survival and death. Here, we critically discuss the mechanisms through which Bcl-2 proteins influence cell fate as they regulate autophagy, cellular senescence, inflammation, bioenergetic metabolism, Ca2+ fluxes, and redox homeostasis.

Original languageEnglish
Pages (from-to)537-555
Number of pages19
JournalTrends in Cell Biology
Volume30
Issue number7
DOIs
StatePublished - Jul 2020
Externally publishedYes

Keywords

  • BCL-X
  • BH3 mimetics
  • MCL1
  • cancer
  • immunity
  • oxidative phosphorylation

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