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Non-NAD-like PARP1 inhibitor enhanced synthetic lethal effect of NAD-like PARP inhibitors against BRCA1-deficient leukemia

  • Margaret Nieborowska-Skorska
  • , Silvia Maifrede
  • , Min Ye
  • , Monika M. Toma
  • , Elizabeth Hewlett
  • , John Gordon
  • , Bac Viet Le
  • , Tomasz Sliwinski
  • , Huaqing Zhao
  • , Katarzyna Piwocka
  • , Peter Valent
  • , Alexei Tulin
  • , Wayne Childers
  • , Tomasz Skorski

Research output: Contribution to journalLetterpeer-review

13 Scopus citations
Original languageEnglish
Pages (from-to)1098-1101
Number of pages4
JournalLeukemia and Lymphoma
Volume60
Issue number4
DOIs
StatePublished - Mar 21 2019

Keywords

  • BRCA1 Protein/deficiency
  • Cell Line, Tumor
  • Cell Survival/drug effects
  • Drug Synergism
  • Humans
  • Leukemia/genetics
  • Phthalazines/pharmacology
  • Piperazines/pharmacology
  • Poly(ADP-ribose) Polymerase Inhibitors/chemistry
  • Synthetic Lethal Mutations/drug effects

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