NK cells beat T cells at early breast cancer control

Aitziber Buque; Norma Bloy; Giulia Petroni; Guido Kroemer; Lorenzo Galluzzi

doi:10.1080/2162402X.2020.1806010

NK cells beat T cells at early breast cancer control

Aitziber Buque
, Norma Bloy
, Giulia Petroni
, Guido Kroemer
, Lorenzo Galluzzi

Cornell University
Université Paris Cité
Assistance publique – Hôpitaux de Paris
Université Paris-Sud
Institute of Blood Transfusion,Chinese Academy of Medical Sciences& Peking Union Medical College
Karolinska Institutet
Weill Cornell Medical College

Research output: Contribution to journal › Editorial

14 Scopus citations

Abstract

Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8⁺ T cells. Our findings demonstrate that CD8⁺ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.

Original language	English
Article number	1806010
Journal	Oncoimmunology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2020.1806010
State	Published - Aug 23 2020
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Hormonotherapy
immune checkpoint blockers
nicotinamide
PD-1
tumor microenvironment
type I interferon
CD8-Positive T-Lymphocytes
Animals
Killer Cells, Natural
Mice
Neoplasms

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10.1080/2162402X.2020.1806010

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@article{087323bb38c7417c8c58067e08707914,

title = "NK cells beat T cells at early breast cancer control",

abstract = "Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.",

keywords = "Hormonotherapy, immune checkpoint blockers, nicotinamide, PD-1, tumor microenvironment, type I interferon, CD8-Positive T-Lymphocytes, Animals, Killer Cells, Natural, Mice, Neoplasms",

author = "Aitziber Buque and Norma Bloy and Giulia Petroni and Guido Kroemer and Lorenzo Galluzzi",

note = "{\textcopyright} 2020 The Author(s). Published with license by Taylor \& Francis Group, LLC.",

year = "2020",

month = aug,

day = "23",

doi = "10.1080/2162402X.2020.1806010",

language = "English",

volume = "9",

journal = "Oncoimmunology",

issn = "2162-4011",

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}

TY - JOUR

T1 - NK cells beat T cells at early breast cancer control

AU - Buque, Aitziber

AU - Bloy, Norma

AU - Petroni, Giulia

AU - Kroemer, Guido

AU - Galluzzi, Lorenzo

PY - 2020/8/23

Y1 - 2020/8/23

N2 - Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.

AB - Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.

KW - Hormonotherapy

KW - immune checkpoint blockers

KW - nicotinamide

KW - PD-1

KW - tumor microenvironment

KW - type I interferon

KW - CD8-Positive T-Lymphocytes

KW - Animals

KW - Killer Cells, Natural

KW - Mice

KW - Neoplasms

UR - https://www.scopus.com/pages/publications/85089751355

U2 - 10.1080/2162402X.2020.1806010

DO - 10.1080/2162402X.2020.1806010

M3 - Editorial

C2 - 32923169

AN - SCOPUS:85089751355

SN - 2162-4011

VL - 9

JO - Oncoimmunology

JF - Oncoimmunology

IS - 1

M1 - 1806010

ER -

NK cells beat T cells at early breast cancer control

Abstract

UN SDGs

Keywords

Access to Document

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