Abstract
Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.
Original language | English |
---|---|
Article number | 1806010 |
Journal | Oncoimmunology |
Volume | 9 |
Issue number | 1 |
DOIs | |
State | Published - Jul 23 2020 |
Externally published | Yes |
Keywords
- Hormonotherapy
- immune checkpoint blockers
- nicotinamide
- PD-1
- tumor microenvironment
- type I interferon
- CD8-Positive T-Lymphocytes
- Animals
- Killer Cells, Natural
- Mice
- Neoplasms