Abstract

Cancer immunosurveillance generally relies on adaptive immune programs executed by CD8+ T cells. Our findings demonstrate that CD8+ T cells fail to control early oncogenesis in a mouse model of luminal B breast cancer and suggest that natural killer (NK) cells may instead play a predominant role in this setting.

Original languageEnglish
Article number1806010
JournalOncoimmunology
Volume9
Issue number1
DOIs
StatePublished - Jul 23 2020
Externally publishedYes

Keywords

  • Hormonotherapy
  • immune checkpoint blockers
  • nicotinamide
  • PD-1
  • tumor microenvironment
  • type I interferon
  • CD8-Positive T-Lymphocytes
  • Animals
  • Killer Cells, Natural
  • Mice
  • Neoplasms

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