Newly discovered penicillin acylase activity of aculeacin A acylase from Actinoplanes utahensis

Jesús Torres-Bacete, Daniel Hormigo, Maribel Stuart, Miguel Arroyo, Pedro Torres, María P. Castillón, Carmen Acebal, José L. García, Isabel De La Mata

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Aculeacin A acylase from Actinoplanes utahensis produced by Streptomyces lividans revealed acylase activities that are able to hydrolyze penicillin V and several natural aliphatic penicillins. Penicillin K was the best substrate, showing a catalytic efficiency of 34.79 mM-1 s-1. Furthermore, aculeacin A acylase was highly thermostable, with a midpoint transition temperature of 81.5°C.

Original languageEnglish
Pages (from-to)5378-5381
Number of pages4
JournalApplied and Environmental Microbiology
Volume73
Issue number16
DOIs
StatePublished - Aug 2007

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