TY - JOUR
T1 - New strategies in ovarian cancer
T2 - Uptake and experience of women at high risk of ovarian cancer who are considering risk-reducing salpingo-oophorectomy
AU - Miller, Suzanne M.
AU - Roussi, Pagona
AU - Daly, Mary B.
AU - Scarpato, John
N1 - ©2010 AACR.
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Here, we review factors associated with uptake of risk-reducing salpingo-oophorectomy by women at increased hereditary risk for ovarian cancer, as well as quality of life issues following surgery. Forty-one research studies identified through PubMed and PsychInfo met inclusion criteria. Older age, having had children, a family history of ovarian cancer, a personal history of breast cancer, prophylactic mastectomy, and BRCA1/2 mutation carrier status increase the likelihood of undergoing surgery. Psychosocial variables predictive of surgery uptake include greater perceived risk of ovarian cancer and cancer-related anxiety. Most women report satisfaction with their decision to undergo surgery and both lower perceived ovarian cancer risk and less cancer-related anxiety as benefits. Hormonal deprivation is the main disadvantage reported, particularly by premenopausal women who are not on hormonal replacement therapy (HRT). The evidence is mixed about satisfaction with the level of information provided prior to surgery, although generally, women report receiving insufficient information about the pros and cons of HRT. These findings indicate that when designing decision aids, demographic, medical history, and psychosocial variables need to be addressed in order to facilitate quality decision making.
AB - Here, we review factors associated with uptake of risk-reducing salpingo-oophorectomy by women at increased hereditary risk for ovarian cancer, as well as quality of life issues following surgery. Forty-one research studies identified through PubMed and PsychInfo met inclusion criteria. Older age, having had children, a family history of ovarian cancer, a personal history of breast cancer, prophylactic mastectomy, and BRCA1/2 mutation carrier status increase the likelihood of undergoing surgery. Psychosocial variables predictive of surgery uptake include greater perceived risk of ovarian cancer and cancer-related anxiety. Most women report satisfaction with their decision to undergo surgery and both lower perceived ovarian cancer risk and less cancer-related anxiety as benefits. Hormonal deprivation is the main disadvantage reported, particularly by premenopausal women who are not on hormonal replacement therapy (HRT). The evidence is mixed about satisfaction with the level of information provided prior to surgery, although generally, women report receiving insufficient information about the pros and cons of HRT. These findings indicate that when designing decision aids, demographic, medical history, and psychosocial variables need to be addressed in order to facilitate quality decision making.
KW - Carcinoma/etiology
KW - Choice Behavior
KW - Decision Making/physiology
KW - Female
KW - Hormone Replacement Therapy/adverse effects
KW - Humans
KW - Medical Oncology/education
KW - Ovarian Neoplasms/etiology
KW - Ovariectomy/education
KW - Patient Education as Topic
KW - Risk Factors
KW - Risk Reduction Behavior
KW - Salpingostomy/education
UR - http://www.scopus.com/inward/record.url?scp=78049478573&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000283668500002&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1158/1078-0432.CCR-09-2953
DO - 10.1158/1078-0432.CCR-09-2953
M3 - Review article
C2 - 20829330
SN - 1078-0432
VL - 16
SP - 5094
EP - 5106
JO - Clinical Cancer Research
JF - Clinical Cancer Research
IS - 21
ER -