New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation

Chrystal Chang; David W. Barham; Zafardjan Dalimov; Daniel Swerdloff; Hossein Sadeghi-Nejad; Robert Andrianne; Maxime Sempels; Tung Chin Hsieh; Georgios Hatzichristodoulou; Muhammed Hammad; Jake Miller; Daniar Osmonov; Aaron Lentz; Paul Perito; Alfredo Suarez-Sarmiento; James Hotaling; Kelli Gross; James M. Jones; Koenraad van Renterghem; Sung Hun Park; Jonathan N. Warner; Matthew Ziegelmann; Vaibhav Modgil; Adam Jones; Ian Pearce; Arthur L. Burnett; Martin S. Gross; Faysal A. Yafi; Jay Simhan

doi:10.1111/bju.16607

New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation

Chrystal Chang, David W. Barham, Zafardjan Dalimov, Daniel Swerdloff, Hossein Sadeghi-Nejad, Robert Andrianne, Maxime Sempels, Tung Chin Hsieh, Georgios Hatzichristodoulou, Muhammed Hammad, Jake Miller, Daniar Osmonov, Aaron Lentz, Paul Perito, Alfredo Suarez-Sarmiento, James Hotaling, Kelli Gross, James M. Jones, Koenraad van Renterghem, Sung Hun ParkJonathan N. Warner, Matthew Ziegelmann, Vaibhav Modgil, Adam Jones, Ian Pearce, Arthur L. Burnett, Martin S. Gross, Faysal A. Yafi, Jay Simhan

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVES: To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.

PATIENTS AND METHODS: We retrospectively reviewed a 16-centre multi-institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra- and postoperative corporal complications.

RESULTS: We identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15-12.92; P < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32-3.39; P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18-2.77; P = 0.006), older age (OR 1.02, 95% CI 1.01-1.04; P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0-2.5; P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18-12.88; P < 0.001), corporal scarring (OR 2.77, 95% CI 1.64-4.69; P < 0.001), radiation therapy (OR 2.25, 95% CI 1.0-5.04; P = 0.049), and older age (OR 1.03, 95% CI 1.0-1.05; P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69-17.01; P < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61-7.19; P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56-5.72; P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08-11.99; P = 0.038) were predictive of pPCI.

CONCLUSION: Coronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient-specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer-term device viability.

Original language	English
Journal	BJU International
DOIs	https://doi.org/10.1111/bju.16607
State	Accepted/In press - 2024

Keywords

Corporal Integrity
Inflatable penile prosthesis
Intraoperative complications
Penile prosthesis erosion
Postoperative complications

Access to Document

10.1111/bju.16607

Cite this

Chang, C., Barham, D. W., Dalimov, Z., Swerdloff, D., Sadeghi-Nejad, H., Andrianne, R., Sempels, M., Hsieh, T. C., Hatzichristodoulou, G., Hammad, M., Miller, J., Osmonov, D., Lentz, A., Perito, P., Suarez-Sarmiento, A., Hotaling, J., Gross, K., Jones, J. M., van Renterghem, K., ... Simhan, J. (Accepted/In press). New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation. BJU International. https://doi.org/10.1111/bju.16607

@article{c7bdee758cd34649b3684e5ac033f6d0,

title = "New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation",

abstract = "OBJECTIVES: To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.PATIENTS AND METHODS: We retrospectively reviewed a 16-centre multi-institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra- and postoperative corporal complications.RESULTS: We identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15-12.92; P < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32-3.39; P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18-2.77; P = 0.006), older age (OR 1.02, 95% CI 1.01-1.04; P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0-2.5; P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18-12.88; P < 0.001), corporal scarring (OR 2.77, 95% CI 1.64-4.69; P < 0.001), radiation therapy (OR 2.25, 95% CI 1.0-5.04; P = 0.049), and older age (OR 1.03, 95% CI 1.0-1.05; P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69-17.01; P < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61-7.19; P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56-5.72; P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08-11.99; P = 0.038) were predictive of pPCI.CONCLUSION: Coronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient-specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer-term device viability.",

keywords = "Corporal Integrity, Inflatable penile prosthesis, Intraoperative complications, Penile prosthesis erosion, Postoperative complications",

author = "Chrystal Chang and Barham, {David W.} and Zafardjan Dalimov and Daniel Swerdloff and Hossein Sadeghi-Nejad and Robert Andrianne and Maxime Sempels and Hsieh, {Tung Chin} and Georgios Hatzichristodoulou and Muhammed Hammad and Jake Miller and Daniar Osmonov and Aaron Lentz and Paul Perito and Alfredo Suarez-Sarmiento and James Hotaling and Kelli Gross and Jones, {James M.} and {van Renterghem}, Koenraad and Park, {Sung Hun} and Warner, {Jonathan N.} and Matthew Ziegelmann and Vaibhav Modgil and Adam Jones and Ian Pearce and Burnett, {Arthur L.} and Gross, {Martin S.} and Yafi, {Faysal A.} and Jay Simhan",

note = "{\textcopyright} 2024 BJU International.",

year = "2024",

doi = "10.1111/bju.16607",

language = "English",

journal = "BJU International",

issn = "1464-4096",

publisher = "John Wiley and Sons Inc.",

}

Chang, C, Barham, DW, Dalimov, Z, Swerdloff, D, Sadeghi-Nejad, H, Andrianne, R, Sempels, M, Hsieh, TC, Hatzichristodoulou, G, Hammad, M, Miller, J, Osmonov, D, Lentz, A, Perito, P, Suarez-Sarmiento, A, Hotaling, J, Gross, K, Jones, JM, van Renterghem, K, Park, SH, Warner, JN, Ziegelmann, M, Modgil, V, Jones, A, Pearce, I, Burnett, AL, Gross, MS, Yafi, FA & Simhan, J 2024, 'New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation', BJU International. https://doi.org/10.1111/bju.16607

TY - JOUR

T1 - New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients

T2 - A Multicenter International Invesigation

AU - Chang, Chrystal

AU - Barham, David W.

AU - Dalimov, Zafardjan

AU - Swerdloff, Daniel

AU - Sadeghi-Nejad, Hossein

AU - Andrianne, Robert

AU - Sempels, Maxime

AU - Hsieh, Tung Chin

AU - Hatzichristodoulou, Georgios

AU - Hammad, Muhammed

AU - Miller, Jake

AU - Osmonov, Daniar

AU - Lentz, Aaron

AU - Perito, Paul

AU - Suarez-Sarmiento, Alfredo

AU - Hotaling, James

AU - Gross, Kelli

AU - Jones, James M.

AU - van Renterghem, Koenraad

AU - Park, Sung Hun

AU - Warner, Jonathan N.

AU - Ziegelmann, Matthew

AU - Modgil, Vaibhav

AU - Jones, Adam

AU - Pearce, Ian

AU - Burnett, Arthur L.

AU - Gross, Martin S.

AU - Yafi, Faysal A.

AU - Simhan, Jay

PY - 2024

Y1 - 2024

N2 - OBJECTIVES: To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.PATIENTS AND METHODS: We retrospectively reviewed a 16-centre multi-institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra- and postoperative corporal complications.RESULTS: We identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15-12.92; P < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32-3.39; P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18-2.77; P = 0.006), older age (OR 1.02, 95% CI 1.01-1.04; P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0-2.5; P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18-12.88; P < 0.001), corporal scarring (OR 2.77, 95% CI 1.64-4.69; P < 0.001), radiation therapy (OR 2.25, 95% CI 1.0-5.04; P = 0.049), and older age (OR 1.03, 95% CI 1.0-1.05; P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69-17.01; P < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61-7.19; P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56-5.72; P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08-11.99; P = 0.038) were predictive of pPCI.CONCLUSION: Coronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient-specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer-term device viability.

AB - OBJECTIVES: To evaluate the pre- and intraoperative variables that impact the integrity of the corporal bodies over time after inflatable penile prosthesis (IPP) placement, as predictors of intraoperative corporal perforation and delayed cylinder complications have not been well characterized.PATIENTS AND METHODS: We retrospectively reviewed a 16-centre multi-institutional database of IPP surgeries performed by experienced implanters from 2016 to 2021. Poor corporal integrity (PCI) was defined as intraoperative (iPCI) corporal complications or postoperative (pPCI) corporal complications. Multivariable analysis was performed to identify independent predictors of PCI, iPCI, and pPCI. Primary outcomes included intra- and postoperative corporal complications.RESULTS: We identified 5153 patients for analysis from 5406 IPP cases, finding 152 (2.95%) cases of PCI. On multivariable analysis, predictors of PCI included revision IPP surgery (odds ratio [OR] 8.16, 95% confidence interval [CI] 5.15-12.92; P < 0.001), sequential dilatation (OR 2.12, 95% CI 1.32-3.39; P = 0.002), coronary artery disease (CAD)/peripheral vascular disease (PVD) (OR 1.81, 95% CI 1.18-2.77; P = 0.006), older age (OR 1.02, 95% CI 1.01-1.04; P = 0.013), and corporal scarring (OR 1.58, 95% CI 1.0-2.5; P = 0.049). Predictors of iPCI included revision IPP surgery (OR 7.34, 95% CI 4.18-12.88; P < 0.001), corporal scarring (OR 2.77, 95% CI 1.64-4.69; P < 0.001), radiation therapy (OR 2.25, 95% CI 1.0-5.04; P = 0.049), and older age (OR 1.03, 95% CI 1.0-1.05; P = 0.025). Revision IPP surgery (OR 7.92, 95% CI 3.69-17.01; P < 0.001), sequential dilatation (OR 3.4, 95% CI 1.61-7.19; P = 0.001), CAD/PVD (OR 2.98, 95% CI 1.56-5.72; P = 0.001), and history of priapism (OR 3.59, 95% CI 1.08-11.99; P = 0.038) were predictive of pPCI.CONCLUSION: Coronary artery disease/PVD, being of older age, having corporal scarring, undergoing IPP revision surgery and sequential dilatation were predictive risk factors for complications associated with PCI. Identifying patients who are at risk of having PCI may improve patient-specific counselling, consideration of referral to more experienced implanters, and surgical planning to potentially promote longer-term device viability.

KW - Corporal Integrity

KW - Inflatable penile prosthesis

KW - Intraoperative complications

KW - Penile prosthesis erosion

KW - Postoperative complications

UR - http://www.scopus.com/inward/record.url?scp=85211483569&partnerID=8YFLogxK

U2 - 10.1111/bju.16607

DO - 10.1111/bju.16607

M3 - Article

C2 - 39658322

AN - SCOPUS:85211483569

SN - 1464-4096

JO - BJU International

JF - BJU International

ER -

New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation

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New Findings from Fox Chase Cancer Center Describe Advances in Penile Implant (New Findings Regarding Predictors of Poor Corporal Integrity In Penile Implant Recipients: a Multicenter International Invesigation)

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New findings regarding predictors of Poor Corporal Integrity in Penile Implant Recipients: A Multicenter International Invesigation

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New Findings from Fox Chase Cancer Center Describe Advances in Penile Implant (New Findings Regarding Predictors of Poor Corporal Integrity In Penile Implant Recipients: a Multicenter International Invesigation)

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