Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome

Kevin Zarrabi; Selma Masic; Christopher Schaefer; Michael J. Bartel; Alexander Kutikov; Matthew Zibelman

doi:10.1016/j.eucr.2019.101077

Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome

Kevin Zarrabi, Selma Masic, Christopher Schaefer, Michael J. Bartel, Alexander Kutikov, Matthew Zibelman

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6 Scopus citations

Abstract

Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.

Original language	English
Article number	101077
Journal	Urology Case Reports
Volume	29
DOIs	https://doi.org/10.1016/j.eucr.2019.101077
State	Published - Mar 2020

Keywords

Immunotherapy
Renal cell carcinoma
Stauffer's syndrome

UN SDGs

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10.1016/j.eucr.2019.101077

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title = "Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome",

abstract = "Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.",

keywords = "Immunotherapy, Renal cell carcinoma, Stauffer's syndrome",

author = "Kevin Zarrabi and Selma Masic and Christopher Schaefer and Bartel, {Michael J.} and Alexander Kutikov and Matthew Zibelman",

note = "Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2020",

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doi = "10.1016/j.eucr.2019.101077",

language = "English",

volume = "29",

journal = "Urology Case Reports",

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T1 - Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome

AU - Zarrabi, Kevin

AU - Masic, Selma

AU - Schaefer, Christopher

AU - Bartel, Michael J.

AU - Kutikov, Alexander

AU - Zibelman, Matthew

PY - 2020/3

Y1 - 2020/3

N2 - Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.

AB - Stauffer's syndrome is a paraneoplastic phenomenon associated with renal cell carcinoma (RCC) characterized by cholestatic hepatitis. We explore the effects of perioperative immunotherapy in a case of Stauffer's syndrome. A 70-year-old female with a locally advanced clear cell RCC (ccRCC) developed severe hyperbilirubinemia. The patient's cholestasis progressed despite initial systemic immunotherapy, but improved after cytoreductive nephrectomy. The patient continued immunotherapy post-operatively and regained normalized hepatic function. To our knowledge, this is the first case reporting use of systemic immunotherapy with surgery in Stauffer's syndrome, and we provide clinical insight into a treatment regimen which may be employed in future cases.

KW - Immunotherapy

KW - Renal cell carcinoma

KW - Stauffer's syndrome

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DO - 10.1016/j.eucr.2019.101077

M3 - Article

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SN - 2214-4420

VL - 29

JO - Urology Case Reports

JF - Urology Case Reports

M1 - 101077

ER -

Neoadjuvant checkpoint inhibition in renal cell carcinoma associated Stauffer's syndrome

Abstract

Keywords

UN SDGs

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