NCCN GUIDELINES® INSIGHTS: Central Nervous System Cancers, Version 2.2022

Craig Horbinski; Louis Burt Nabors; Jana Portnow; Joachim Baehring; Ankush Bhatia; Orin Bloch; Steven Brem; Nicholas Butowski; Donald M. Cannon; Samuel Chao; Milan G. Chheda; Andrew J. Fabiano; Peter Forsyth; Pierre Gigilio; Jona Hattangadi-Gluth; Matthias Holdhoff; Larry Junck; Thomas Kaley; Ryan Merrell; Maciej M. Mrugala; Seema Nagpal; Lucien A. Nedzi; Kathryn Nevel; Phioanh L. Nghiemphu; Ian Parney; Toral R. Patel; Katherine Peters; Vinay K. Puduvalli; Jason Rockhill; Chad Rusthoven; Nicole Shonka; Lode J. Swinnen; Stephanie Weiss; Patrick Yung Wen; Nicole E. Willmarth; Mary Anne Bergman; Susan Darlow

doi:10.6004/jnccn.2023.0002

NCCN GUIDELINES^® INSIGHTS: Central Nervous System Cancers, Version 2.2022

Craig Horbinski
, Louis Burt Nabors
, Jana Portnow
, Joachim Baehring
, Ankush Bhatia
, Orin Bloch
, Steven Brem
, Nicholas Butowski
, Donald M. Cannon
, Samuel Chao
, Milan G. Chheda
, Andrew J. Fabiano
, Peter Forsyth
, Pierre Gigilio
, Jona Hattangadi-Gluth
, Matthias Holdhoff
, Larry Junck
, Thomas Kaley
, Ryan Merrell
, Maciej M. Mrugala

Seema Nagpal, Lucien A. Nedzi, Kathryn Nevel, Phioanh L. Nghiemphu, Ian Parney, Toral R. Patel, Katherine Peters, Vinay K. Puduvalli, Jason Rockhill, Chad Rusthoven, Nicole Shonka, Lode J. Swinnen, Stephanie Weiss, Patrick Yung Wen, Nicole E. Willmarth, Mary Anne Bergman, Susan Darlow

Northwestern University
University of Alabama at Birmingham
City of Hope National Medical Center
Yale University
University of Wisconsin-Madison
University of California at Davis
University of Pennsylvania
University of California at San Francisco
University of Utah
Case Western Reserve University
Washington University St. Louis
Roswell Park Comprehensive Cancer Center
University of South Florida
Ohio State University
University of California at San Diego
Johns Hopkins University
University of Michigan, Ann Arbor
Memorial Sloan-Kettering Cancer Center
Vanderbilt University
Mayo Clinic
Stanford University
University of Tennessee Health Science Center
Indiana University Bloomington
University of California at Los Angeles
UT Southwestern Simmons Comprehensive Cancer Center
Duke University
Fred Hutchinson Cancer Research Center
University of Colorado Anschutz Medical Campus
University of Nebraska Medical Center
Dana-Farber Cancer Institute
American Brain Tumor Association
National Comprehensive Cancer Network

Research output: Contribution to journal › Article › peer-review

210 Scopus citations

Abstract

The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2–3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2–4 IDH-mutant astrocytoma, WHO grade 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited and extensive brain metastases, leptomeningeal metastases, non–AIDS-related primary CNS lymphomas, metastatic spine tumors, meningiomas, and primary spinal cord tumors. The information contained in the algorithms and principles of management sections in the NCCN Guidelines for CNS Cancers are designed to help clinicians navigate through the complex management of patients with CNS tumors. Several important principles guide surgical management and treatment with radiotherapy and systemic therapy for adults with brain tumors. The NCCN CNS Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel’s most recent recommendations regarding molecular profiling of gliomas.

Original language	English
Pages (from-to)	12-20
Number of pages	9
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	21
Issue number	1
DOIs	https://doi.org/10.6004/jnccn.2023.0002
State	Published - Jan 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Adult
Brain Neoplasms/diagnosis
Central Nervous System
Central Nervous System Neoplasms/diagnosis
Humans
Mutation

Access to Document

10.6004/jnccn.2023.0002

Cite this

Horbinski, C., Nabors, L. B., Portnow, J., Baehring, J., Bhatia, A., Bloch, O., Brem, S., Butowski, N., Cannon, D. M., Chao, S., Chheda, M. G., Fabiano, A. J., Forsyth, P., Gigilio, P., Hattangadi-Gluth, J., Holdhoff, M., Junck, L., Kaley, T., Merrell, R., ... Darlow, S. (2023). NCCN GUIDELINES^® INSIGHTS: Central Nervous System Cancers, Version 2.2022. JNCCN Journal of the National Comprehensive Cancer Network, 21(1), 12-20. https://doi.org/10.6004/jnccn.2023.0002

@article{92e2f13ae55847a7b17f625b2cbffc0f,

title = "NCCN GUIDELINES{\textregistered} INSIGHTS: Central Nervous System Cancers, Version 2.2022",

abstract = "The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2{\textendash}3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2{\textendash}4 IDH-mutant astrocytoma, WHO grade 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited and extensive brain metastases, leptomeningeal metastases, non{\textendash}AIDS-related primary CNS lymphomas, metastatic spine tumors, meningiomas, and primary spinal cord tumors. The information contained in the algorithms and principles of management sections in the NCCN Guidelines for CNS Cancers are designed to help clinicians navigate through the complex management of patients with CNS tumors. Several important principles guide surgical management and treatment with radiotherapy and systemic therapy for adults with brain tumors. The NCCN CNS Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel{\textquoteright}s most recent recommendations regarding molecular profiling of gliomas.",

keywords = "Adult, Brain Neoplasms/diagnosis, Central Nervous System, Central Nervous System Neoplasms/diagnosis, Humans, Mutation",

author = "Craig Horbinski and Nabors, \{Louis Burt\} and Jana Portnow and Joachim Baehring and Ankush Bhatia and Orin Bloch and Steven Brem and Nicholas Butowski and Cannon, \{Donald M.\} and Samuel Chao and Chheda, \{Milan G.\} and Fabiano, \{Andrew J.\} and Peter Forsyth and Pierre Gigilio and Jona Hattangadi-Gluth and Matthias Holdhoff and Larry Junck and Thomas Kaley and Ryan Merrell and Mrugala, \{Maciej M.\} and Seema Nagpal and Nedzi, \{Lucien A.\} and Kathryn Nevel and Nghiemphu, \{Phioanh L.\} and Ian Parney and Patel, \{Toral R.\} and Katherine Peters and Puduvalli, \{Vinay K.\} and Jason Rockhill and Chad Rusthoven and Nicole Shonka and Swinnen, \{Lode J.\} and Stephanie Weiss and Wen, \{Patrick Yung\} and Willmarth, \{Nicole E.\} and Bergman, \{Mary Anne\} and Susan Darlow",

year = "2023",

month = jan,

doi = "10.6004/jnccn.2023.0002",

language = "English",

volume = "21",

pages = "12--20",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

issn = "1540-1405",

publisher = "Harborside Press",

number = "1",

}

Horbinski, C, Nabors, LB, Portnow, J, Baehring, J, Bhatia, A, Bloch, O, Brem, S, Butowski, N, Cannon, DM, Chao, S, Chheda, MG, Fabiano, AJ, Forsyth, P, Gigilio, P, Hattangadi-Gluth, J, Holdhoff, M, Junck, L, Kaley, T, Merrell, R, Mrugala, MM, Nagpal, S, Nedzi, LA, Nevel, K, Nghiemphu, PL, Parney, I, Patel, TR, Peters, K, Puduvalli, VK, Rockhill, J, Rusthoven, C, Shonka, N, Swinnen, LJ, Weiss, S, Wen, PY, Willmarth, NE, Bergman, MA & Darlow, S 2023, 'NCCN GUIDELINES^® INSIGHTS: Central Nervous System Cancers, Version 2.2022', JNCCN Journal of the National Comprehensive Cancer Network, vol. 21, no. 1, pp. 12-20. https://doi.org/10.6004/jnccn.2023.0002

TY - JOUR

T1 - NCCN GUIDELINES® INSIGHTS

T2 - Central Nervous System Cancers, Version 2.2022

AU - Horbinski, Craig

AU - Nabors, Louis Burt

AU - Portnow, Jana

AU - Baehring, Joachim

AU - Bhatia, Ankush

AU - Bloch, Orin

AU - Brem, Steven

AU - Butowski, Nicholas

AU - Cannon, Donald M.

AU - Chao, Samuel

AU - Chheda, Milan G.

AU - Fabiano, Andrew J.

AU - Forsyth, Peter

AU - Gigilio, Pierre

AU - Hattangadi-Gluth, Jona

AU - Holdhoff, Matthias

AU - Junck, Larry

AU - Kaley, Thomas

AU - Merrell, Ryan

AU - Mrugala, Maciej M.

AU - Nagpal, Seema

AU - Nedzi, Lucien A.

AU - Nevel, Kathryn

AU - Nghiemphu, Phioanh L.

AU - Parney, Ian

AU - Patel, Toral R.

AU - Peters, Katherine

AU - Puduvalli, Vinay K.

AU - Rockhill, Jason

AU - Rusthoven, Chad

AU - Shonka, Nicole

AU - Swinnen, Lode J.

AU - Weiss, Stephanie

AU - Wen, Patrick Yung

AU - Willmarth, Nicole E.

AU - Bergman, Mary Anne

AU - Darlow, Susan

PY - 2023/1

Y1 - 2023/1

N2 - The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2–3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2–4 IDH-mutant astrocytoma, WHO grade 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited and extensive brain metastases, leptomeningeal metastases, non–AIDS-related primary CNS lymphomas, metastatic spine tumors, meningiomas, and primary spinal cord tumors. The information contained in the algorithms and principles of management sections in the NCCN Guidelines for CNS Cancers are designed to help clinicians navigate through the complex management of patients with CNS tumors. Several important principles guide surgical management and treatment with radiotherapy and systemic therapy for adults with brain tumors. The NCCN CNS Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel’s most recent recommendations regarding molecular profiling of gliomas.

AB - The NCCN Guidelines for Central Nervous System (CNS) Cancers focus on management of the following adult CNS cancers: glioma (WHO grade 1, WHO grade 2–3 oligodendroglioma [1p19q codeleted, IDH-mutant], WHO grade 2–4 IDH-mutant astrocytoma, WHO grade 4 glioblastoma), intracranial and spinal ependymomas, medulloblastoma, limited and extensive brain metastases, leptomeningeal metastases, non–AIDS-related primary CNS lymphomas, metastatic spine tumors, meningiomas, and primary spinal cord tumors. The information contained in the algorithms and principles of management sections in the NCCN Guidelines for CNS Cancers are designed to help clinicians navigate through the complex management of patients with CNS tumors. Several important principles guide surgical management and treatment with radiotherapy and systemic therapy for adults with brain tumors. The NCCN CNS Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel’s most recent recommendations regarding molecular profiling of gliomas.

KW - Adult

KW - Brain Neoplasms/diagnosis

KW - Central Nervous System

KW - Central Nervous System Neoplasms/diagnosis

KW - Humans

KW - Mutation

UR - https://www.scopus.com/pages/publications/85146195028

U2 - 10.6004/jnccn.2023.0002

DO - 10.6004/jnccn.2023.0002

M3 - Article

C2 - 36634606

AN - SCOPUS:85146195028

SN - 1540-1405

VL - 21

SP - 12

EP - 20

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 1

ER -