NCCN Guidelines® Insights: Head and Neck Cancers, Version 2.2025

A. Dimitrios Colevas; Anthony J. Cmelak; David G. Pfister; Sharon Spencer; Douglas Adkins; Andrew C. Birkeland; David M. Brizel; Paul M. Busse; Jimmy J. Caudell; Greg Durm; Carole Fakhry; Thomas Galloway; Jessica L. Geiger; Maura L. Gillison; Christine Glastonbury; Robert I. Haddad; Wesley L. Hicks; Ying J. Hitchcock; Antonio Jimeno; Aditya Juloori; Michael Kase; Debra Leizman; Ellie Maghami; Loren K. Mell; Bharat B. Mittal; Harlan A. Pinto; Katharine Price; James W. Rocco; Cristina P. Rodriguez; David Schwartz; Jatin P. Shah; David Sher; Maie St John; He Wang; Gregory Weinstein; Francis Worden; Justine Yang Bruce; Sue S. Yom; Weining Zhen; Sarah Montgomery; Susan D. Darlow

doi:10.6004/jnccn.2025.0007

NCCN Guidelines® Insights: Head and Neck Cancers, Version 2.2025

A. Dimitrios Colevas
, Anthony J. Cmelak
, David G. Pfister
, Sharon Spencer
, Douglas Adkins
, Andrew C. Birkeland
, David M. Brizel
, Paul M. Busse
, Jimmy J. Caudell
, Greg Durm
, Carole Fakhry
, Thomas Galloway
, Jessica L. Geiger
, Maura L. Gillison
, Christine Glastonbury
, Robert I. Haddad
, Wesley L. Hicks
, Ying J. Hitchcock
, Antonio Jimeno
, Aditya Juloori

Michael Kase, Debra Leizman, Ellie Maghami, Loren K. Mell, Bharat B. Mittal, Harlan A. Pinto, Katharine Price, James W. Rocco, Cristina P. Rodriguez, David Schwartz, Jatin P. Shah, David Sher, Maie St John, He Wang, Gregory Weinstein, Francis Worden, Justine Yang Bruce, Sue S. Yom, Weining Zhen, Sarah Montgomery, Susan D. Darlow

Stanford University
Vanderbilt University
Memorial Sloan-Kettering Cancer Center
University of Alabama at Birmingham
Washington University St. Louis
University of California at Davis
Duke University
Mass General Cancer Center
Moffitt Cancer Center
Indiana University Bloomington
Johns Hopkins University
Case Western Reserve University
University of Texas MD Anderson Cancer Center
University of California at San Francisco
Dana-Farber/Brigham and Women's Cancer Center
Roswell Park Comprehensive Cancer Center
University of Utah
University of Colorado Anschutz Medical Campus
UChicago Medicine Comprehensive Cancer Center
City of Hope National Medical Center
University of California at San Diego
Northwestern University
Mayo Clinic
Ohio State University
Fred Hutchinson Cancer Research Center
University of Tennessee Health Science Center
UT Southwestern Simmons Comprehensive Cancer Center
University of California at Los Angeles
Yale University
University of Pennsylvania
University of Michigan, Ann Arbor
University of Wisconsin-Madison
University of Nebraska Medical Center
National Comprehensive Cancer Network

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses, as well as occult primary cancer, salivary gland cancer, and mucosal melanoma (MM). The specific site of disease, stage, and pathologic findings guide treatment (eg, the appropriate surgical procedure, radiation targets, dose and fractionation of radiation, indications for systemic therapy). The NCCN Head and Neck Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of nasopharynx cancer and ongoing research in this area.

Original language	English
Pages (from-to)	2-11
Number of pages	10
Journal	JNCCN Journal of the National Comprehensive Cancer Network
Volume	23
Issue number	2
DOIs	https://doi.org/10.6004/jnccn.2025.0007
State	Published - Feb 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Education, Medical, Continuing
Head and Neck Neoplasms/therapy
Humans
Practice Guidelines as Topic

Access to Document

10.6004/jnccn.2025.0007

Cite this

Colevas, A. D., Cmelak, A. J., Pfister, D. G., Spencer, S., Adkins, D., Birkeland, A. C., Brizel, D. M., Busse, P. M., Caudell, J. J., Durm, G., Fakhry, C., Galloway, T., Geiger, J. L., Gillison, M. L., Glastonbury, C., Haddad, R. I., Hicks, W. L., Hitchcock, Y. J., Jimeno, A., ... Darlow, S. D. (2025). NCCN Guidelines® Insights: Head and Neck Cancers, Version 2.2025. JNCCN Journal of the National Comprehensive Cancer Network, 23(2), 2-11. https://doi.org/10.6004/jnccn.2025.0007

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title = "NCCN Guidelines{\textregistered} Insights: Head and Neck Cancers, Version 2.2025",

abstract = "The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses, as well as occult primary cancer, salivary gland cancer, and mucosal melanoma (MM). The specific site of disease, stage, and pathologic findings guide treatment (eg, the appropriate surgical procedure, radiation targets, dose and fractionation of radiation, indications for systemic therapy). The NCCN Head and Neck Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of nasopharynx cancer and ongoing research in this area.",

keywords = "Education, Medical, Continuing, Head and Neck Neoplasms/therapy, Humans, Practice Guidelines as Topic",

author = "Colevas, \{A. Dimitrios\} and Cmelak, \{Anthony J.\} and Pfister, \{David G.\} and Sharon Spencer and Douglas Adkins and Birkeland, \{Andrew C.\} and Brizel, \{David M.\} and Busse, \{Paul M.\} and Caudell, \{Jimmy J.\} and Greg Durm and Carole Fakhry and Thomas Galloway and Geiger, \{Jessica L.\} and Gillison, \{Maura L.\} and Christine Glastonbury and Haddad, \{Robert I.\} and Hicks, \{Wesley L.\} and Hitchcock, \{Ying J.\} and Antonio Jimeno and Aditya Juloori and Michael Kase and Debra Leizman and Ellie Maghami and Mell, \{Loren K.\} and Mittal, \{Bharat B.\} and Pinto, \{Harlan A.\} and Katharine Price and Rocco, \{James W.\} and Rodriguez, \{Cristina P.\} and David Schwartz and Shah, \{Jatin P.\} and David Sher and John, \{Maie St\} and He Wang and Gregory Weinstein and Francis Worden and Bruce, \{Justine Yang\} and Yom, \{Sue S.\} and Weining Zhen and Sarah Montgomery and Darlow, \{Susan D.\}",

note = "Publisher Copyright: {\textcopyright} JNCCN{\textemdash}Journal of the National Comprehensive Cancer Network.",

year = "2025",

month = feb,

doi = "10.6004/jnccn.2025.0007",

language = "English",

volume = "23",

pages = "2--11",

journal = "JNCCN Journal of the National Comprehensive Cancer Network",

issn = "1540-1405",

publisher = "Harborside Press",

number = "2",

}

Colevas, AD, Cmelak, AJ, Pfister, DG, Spencer, S, Adkins, D, Birkeland, AC, Brizel, DM, Busse, PM, Caudell, JJ, Durm, G, Fakhry, C, Galloway, T, Geiger, JL, Gillison, ML, Glastonbury, C, Haddad, RI, Hicks, WL, Hitchcock, YJ, Jimeno, A, Juloori, A, Kase, M, Leizman, D, Maghami, E, Mell, LK, Mittal, BB, Pinto, HA, Price, K, Rocco, JW, Rodriguez, CP, Schwartz, D, Shah, JP, Sher, D, John, MS, Wang, H, Weinstein, G, Worden, F, Bruce, JY, Yom, SS, Zhen, W, Montgomery, S & Darlow, SD 2025, 'NCCN Guidelines® Insights: Head and Neck Cancers, Version 2.2025', JNCCN Journal of the National Comprehensive Cancer Network, vol. 23, no. 2, pp. 2-11. https://doi.org/10.6004/jnccn.2025.0007

TY - JOUR

T1 - NCCN Guidelines® Insights

T2 - Head and Neck Cancers, Version 2.2025

AU - Colevas, A. Dimitrios

AU - Cmelak, Anthony J.

AU - Pfister, David G.

AU - Spencer, Sharon

AU - Adkins, Douglas

AU - Birkeland, Andrew C.

AU - Brizel, David M.

AU - Busse, Paul M.

AU - Caudell, Jimmy J.

AU - Durm, Greg

AU - Fakhry, Carole

AU - Galloway, Thomas

AU - Geiger, Jessica L.

AU - Gillison, Maura L.

AU - Glastonbury, Christine

AU - Haddad, Robert I.

AU - Hicks, Wesley L.

AU - Hitchcock, Ying J.

AU - Jimeno, Antonio

AU - Juloori, Aditya

AU - Kase, Michael

AU - Leizman, Debra

AU - Maghami, Ellie

AU - Mell, Loren K.

AU - Mittal, Bharat B.

AU - Pinto, Harlan A.

AU - Price, Katharine

AU - Rocco, James W.

AU - Rodriguez, Cristina P.

AU - Schwartz, David

AU - Shah, Jatin P.

AU - Sher, David

AU - John, Maie St

AU - Wang, He

AU - Weinstein, Gregory

AU - Worden, Francis

AU - Bruce, Justine Yang

AU - Yom, Sue S.

AU - Zhen, Weining

AU - Montgomery, Sarah

AU - Darlow, Susan D.

PY - 2025/2

Y1 - 2025/2

N2 - The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses, as well as occult primary cancer, salivary gland cancer, and mucosal melanoma (MM). The specific site of disease, stage, and pathologic findings guide treatment (eg, the appropriate surgical procedure, radiation targets, dose and fractionation of radiation, indications for systemic therapy). The NCCN Head and Neck Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of nasopharynx cancer and ongoing research in this area.

AB - The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, and paranasal sinuses, as well as occult primary cancer, salivary gland cancer, and mucosal melanoma (MM). The specific site of disease, stage, and pathologic findings guide treatment (eg, the appropriate surgical procedure, radiation targets, dose and fractionation of radiation, indications for systemic therapy). The NCCN Head and Neck Cancers Panel meets at least annually to review comments from reviewers within their institutions, examine relevant new data from publications and abstracts, and reevaluate and update their recommendations. These NCCN Guidelines Insights summarize the panel's most recent recommendations regarding management of nasopharynx cancer and ongoing research in this area.

KW - Education, Medical, Continuing

KW - Head and Neck Neoplasms/therapy

KW - Humans

KW - Practice Guidelines as Topic

UR - https://www.scopus.com/pages/publications/85217976760

U2 - 10.6004/jnccn.2025.0007

DO - 10.6004/jnccn.2025.0007

M3 - Article

C2 - 39938471

AN - SCOPUS:85217976760

SN - 1540-1405

VL - 23

SP - 2

EP - 11

JO - JNCCN Journal of the National Comprehensive Cancer Network

JF - JNCCN Journal of the National Comprehensive Cancer Network

IS - 2

ER -

NCCN Guidelines® Insights: Head and Neck Cancers, Version 2.2025

Abstract

UN SDGs

Keywords

Access to Document

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