TY - JOUR
T1 - Nanomedicine Strategies for Targeting Tumor Stroma
AU - Su, Mei Chi
AU - Nethi, Susheel Kumar
AU - Dhanyamraju, Pavan Kumar
AU - Prabha, Swayam
N1 - Publisher Copyright:
© 2023 by the authors.
PY - 2023/8
Y1 - 2023/8
N2 - The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies.
AB - The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies.
KW - cancer therapy
KW - cancer-associated fibroblasts
KW - collagen
KW - extracellular matrix
KW - fibronectin
KW - hyaluronic acid
KW - nanomedicine
KW - tumor microenvironment
UR - http://www.scopus.com/inward/record.url?scp=85168804472&partnerID=8YFLogxK
UR - https://www.mdpi.com/2072-6694/15/16/4145
U2 - 10.3390/cancers15164145
DO - 10.3390/cancers15164145
M3 - Review article
C2 - 37627173
SN - 2072-6694
VL - 15
JO - Cancers
JF - Cancers
IS - 16
M1 - 4145
ER -