Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2

Kerry S. Campbell

doi:10.1158/2326-6066.CIR-20-0996

Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2

Kerry S. Campbell

Research output: Contribution to journal › Comment/debate

11 Scopus citations

Abstract

Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2 + tumor cells from immune attack. See article by Bhatt et al., p. 156.

Original language	English
Pages (from-to)	128
Number of pages	1
Journal	Cancer Immunology Research
Volume	9
Issue number	2
DOIs	https://doi.org/10.1158/2326-6066.CIR-20-0996
State	Published - Feb 1 2021

Keywords

Immunoglobulins
Killer Cells, Natural
Ligands
Receptors, KIR

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1158/2326-6066.CIR-20-0996

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title = "Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2",

abstract = "Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2 + tumor cells from immune attack. See article by Bhatt et al., p. 156. ",

keywords = "Immunoglobulins, Killer Cells, Natural, Ligands, Receptors, KIR",

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note = "{\textcopyright}2021 American Association for Cancer Research.",

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AU - Campbell, Kerry S.

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N2 - Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2 + tumor cells from immune attack. See article by Bhatt et al., p. 156.

AB - Inhibitory killer cell immunoglobulin-like receptors (iKIR) tolerize natural killer cells and some T cells upon detecting classical HLA class I molecules. In this issue, Bhatt and colleagues identify the B7 family member HHLA2 as an unanticipated ligand for a peculiar iKIR family member, KIR3DL3. These data establish a new inhibitory checkpoint pathway that may protect HHLA2 + tumor cells from immune attack. See article by Bhatt et al., p. 156.

KW - Immunoglobulins

KW - Killer Cells, Natural

KW - Ligands

KW - Receptors, KIR

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U2 - 10.1158/2326-6066.CIR-20-0996

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M3 - Comment/debate

C2 - 33536266

AN - SCOPUS:85100400965

SN - 2326-6066

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SP - 128

JO - Cancer Immunology Research

JF - Cancer Immunology Research

IS - 2

ER -

Mystery checkpoint revealed: KIR3DL3 finally found a ligand in HHLA2

Abstract

Keywords

UN SDGs

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