Abstract
Pleomorphic adenoma (PA) is the most common salivary gland neoplasm worldwide (50%-70%). Most cases of PA are straightforward diagnoses. However, the diagnosis may be challenging due to the morphological diversity of PAs, which in many cases is caused by the predominance of one of the three components or the presence of metaplastic epithelium. We present the case of a 64-year-old male with a history of prostate cancer and right submandibular gland excision 16 years ago with an unknown previous diagnosis and recent regrowth of his mass in the surgical bed. The tumour showed a predominant spindle cell morphology, cytokeratin-positivity, variable expression of myoepithelial markers in the cytology and surgical pathology specimens, and novel inversion of the chromosome 8, and LRP1B, PBRM1 and TCF3 mutations.
| Original language | English |
|---|---|
| Pages (from-to) | 180-186 |
| Number of pages | 7 |
| Journal | Cytopathology |
| Volume | 36 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2025 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Humans
- Male
- Middle Aged
- Adenoma, Pleomorphic/genetics
- DNA-Binding Proteins/genetics
- Mutation/genetics
- Transcription Factors/genetics
- Chromosomes, Human, Pair 8/genetics
- Salivary Gland Neoplasms/genetics
- Nuclear Proteins/genetics
- LDL-Receptor Related Proteins/genetics
- Receptors, LDL
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