Multifaceted control of T cell differentiation by STIM1

Scott Gross, Lauren Womer, Dietmar J. Kappes, Jonathan Soboloff

Research output: Contribution to journalReview articlepeer-review

Abstract

In T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM1 (POST) in controlling Orai function. A major knowledge gap also exists regarding the independence of T cell development from STIM and Orai, despite compelling evidence that it requires Ca2+ signals. Resolving these and other outstanding questions ensures that the field will remain active for many years to come.

Original languageEnglish
Pages (from-to)1083-1097
Number of pages15
JournalTrends in Biochemical Sciences
Volume48
Issue number12
DOIs
StatePublished - Dec 2023

Keywords

  • Calcium Signaling/physiology
  • Calcium/metabolism
  • Cell Differentiation
  • Cell Membrane/metabolism
  • ORAI1 Protein/metabolism
  • Stromal Interaction Molecule 1/metabolism

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