TY - JOUR
T1 - Multifaceted control of T cell differentiation by STIM1
AU - Gross, Scott
AU - Womer, Lauren
AU - Kappes, Dietmar J.
AU - Soboloff, Jonathan
N1 - Publisher Copyright:
© 2023 Elsevier Ltd
PY - 2023/12
Y1 - 2023/12
N2 - In T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM1 (POST) in controlling Orai function. A major knowledge gap also exists regarding the independence of T cell development from STIM and Orai, despite compelling evidence that it requires Ca2+ signals. Resolving these and other outstanding questions ensures that the field will remain active for many years to come.
AB - In T cells, stromal interaction molecule (STIM) and Orai are dispensable for conventional T cell development, but critical for activation and differentiation. This review focuses on novel STIM-dependent mechanisms for control of Ca2+ signals during T cell activation and its impact on mitochondrial function and transcriptional activation for control of T cell differentiation and function. We highlight areas that require further work including the roles of plasma membrane Ca2+ ATPase (PMCA) and partner of STIM1 (POST) in controlling Orai function. A major knowledge gap also exists regarding the independence of T cell development from STIM and Orai, despite compelling evidence that it requires Ca2+ signals. Resolving these and other outstanding questions ensures that the field will remain active for many years to come.
KW - Calcium Signaling/physiology
KW - Calcium/metabolism
KW - Cell Differentiation
KW - Cell Membrane/metabolism
KW - ORAI1 Protein/metabolism
KW - Stromal Interaction Molecule 1/metabolism
UR - http://www.scopus.com/inward/record.url?scp=85170218461&partnerID=8YFLogxK
U2 - 10.1016/j.tibs.2023.08.006
DO - 10.1016/j.tibs.2023.08.006
M3 - Review article
C2 - 37696713
SN - 0968-0004
VL - 48
SP - 1083
EP - 1097
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 12
ER -