mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

Israel Cañadas; Takahiko Murayama; Lorenzo Galluzzi

doi:10.1016/j.trecan.2025.06.010

mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

Israel Cañadas
, Takahiko Murayama
, Lorenzo Galluzzi

Fox Chase Cancer Center

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence. Lai et al. have recently demonstrated that this may be accompanied by mtDNA release within extracellular vesicles that promote local immunosuppression via myeloid-derived suppressor cells.

Original language	English
Pages (from-to)	716-718
Number of pages	3
Journal	Trends in Cancer
Volume	11
Issue number	8
Early online date	Jul 2 2025
DOIs	https://doi.org/10.1016/j.trecan.2025.06.010
State	Published - Aug 2025

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

NF-κB
PD-L1
SASP
STING
VDAC
prostate cancer

Access to Document

10.1016/j.trecan.2025.06.010

Cite this

@article{13524176fea54befa0b4105144c8e90c,

title = "mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression",

abstract = "Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence. Lai et al. have recently demonstrated that this may be accompanied by mtDNA release within extracellular vesicles that promote local immunosuppression via myeloid-derived suppressor cells.",

keywords = "NF-κB, PD-L1, SASP, STING, VDAC, prostate cancer",

author = "Israel Ca{\~n}adas and Takahiko Murayama and Lorenzo Galluzzi",

year = "2025",

month = aug,

doi = "10.1016/j.trecan.2025.06.010",

language = "English",

volume = "11",

pages = "716--718",

journal = "Trends in Cancer",

issn = "2405-8033",

publisher = "Cell Press",

number = "8",

}

TY - JOUR

T1 - mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

AU - Cañadas, Israel

AU - Murayama, Takahiko

AU - Galluzzi, Lorenzo

PY - 2025/8

Y1 - 2025/8

N2 - Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence. Lai et al. have recently demonstrated that this may be accompanied by mtDNA release within extracellular vesicles that promote local immunosuppression via myeloid-derived suppressor cells.

AB - Sublethal apoptotic stress causing the permeabilization of some mitochondria coupled with cytosolic mitochondrial DNA (mtDNA) accumulation is known to promote cellular senescence. Lai et al. have recently demonstrated that this may be accompanied by mtDNA release within extracellular vesicles that promote local immunosuppression via myeloid-derived suppressor cells.

KW - NF-κB

KW - PD-L1

KW - SASP

KW - STING

KW - VDAC

KW - prostate cancer

UR - https://www.scopus.com/pages/publications/105009469767

U2 - 10.1016/j.trecan.2025.06.010

DO - 10.1016/j.trecan.2025.06.010

M3 - Article

C2 - 40610348

AN - SCOPUS:105009469767

SN - 2405-8033

VL - 11

SP - 716

EP - 718

JO - Trends in Cancer

JF - Trends in Cancer

IS - 8

ER -

mtDNA transfer from senescent cancer cells to MDSCs promotes immunosuppression

Abstract

UN SDGs

Keywords

Access to Document

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