Abstract
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Zoological research |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2021 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- Epithelial ovarian cancer
- Genetic engineered mouse model
- Intraperitoneal mouse model
- Orthotopic mouse model
- Patientderived xenografts
- Subcutaneous mouse model
- Syngeneic mouse model
- Antineoplastic Agents/therapeutic use
- Ovarian Neoplasms/drug therapy
- Animals
- Female
- Mice
- Drug Evaluation, Preclinical
- Disease Models, Animal
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