Abstract
Epithelial ovarian cancer (EOC) is the leading cause of gynecological cancer-related mortality in the developed world. EOC is a heterogeneous disease represented by several histological and molecular subtypes. Therefore, exploration of relevant preclinical animal models that consider the heterogenic nature of EOC is of great importance for the development of novel therapeutic strategies that can be translated clinically to combat this devastating disease. In this review, we discuss recent progress in the development of preclinical mouse models for EOC study as well as their advantages and limitations.
| Original language | English |
|---|---|
| Pages (from-to) | 153-160 |
| Number of pages | 8 |
| Journal | Zoological research |
| Volume | 42 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2021 |
| Externally published | Yes |
Keywords
- Animals Antineoplastic Agents/*therapeutic use *Disease Models, Animal Drug Evaluation, Preclinical Female Mice Ovarian Neoplasms/*drug therapy Epithelial ovarian cancer Genetic engineered mouse model Intraperitoneal mouse model Orthotopic mouse model Patient-derived xenografts Subcutaneous mouse model Syngeneic mouse model
