TY - JOUR
T1 - Mother-child cardiometabolic health 4-10 years after pregnancy complicated by obesity with and without gestational diabetes
AU - Martin, Samantha L
AU - Zhang, Li
AU - Callahan, Makenzie L
AU - Bahorski, Jessica
AU - Lewis, Cora E
AU - Hidalgo, Bertha A
AU - Durant, Nefertiti
AU - Harper, Lorie M
AU - Battarbee, Ashley N
AU - Habegger, Kirk
AU - Moore, Bethany A
AU - Everett, Alysha
AU - Aslibekyan, Stella
AU - Sertie, Rogerio
AU - Yi, Nengjun
AU - Garvey, W Timothy
AU - Chandler-Laney, Paula
N1 - Publisher Copyright:
© 2022 The Authors. Obesity Science & Practice published by World Obesity and The Obesity Society and John Wiley & Sons Ltd.
PY - 2022/2/16
Y1 - 2022/2/16
N2 - OBJECTIVE: Obesity in pregnancy and gestational diabetes (GDM) increase cardiometabolic disease risk but are difficult to disentangle. This study aimed to test the hypothesis that 4-10 years after a pregnancy complicated by overweight/obesity and GDM (OB-GDM), women and children would have greater adiposity and poorer cardiometabolic health than those with overweight/obesity (OB) or normal weight (NW) and no GDM during the index pregnancy.METHODS: In this cross-sectional study, mother-child dyads were stratified into three groups based on maternal health status during pregnancy (OB-GDM = 67; OB = 76; NW = 76). Weight, height, waist and hip circumferences, and blood pressure were measured, along with fasting glucose, insulin, HbA1c, lipids, adipokines, and cytokines.RESULTS: Women in the OB and OB-GDM groups had greater current adiposity and poorer cardiometabolic health outcomes than those in the NW group (p < 0.05). After adjusting for current adiposity, women in the OB-GDM group had higher HbA1c, glucose, HOMA-IR and triglycerides than NW and OB groups (p < 0.05). Among children, adiposity was greater in the OB-GDM versus NW group (p < 0.05), but other indices of cardiometabolic health did not differ.CONCLUSIONS: Poor cardiometabolic health in women with prior GDM is independent of current adiposity. Although greater adiposity among children exposed to GDM is evident at 4-10 years, differences in cardiometabolic health may not emerge until later.
AB - OBJECTIVE: Obesity in pregnancy and gestational diabetes (GDM) increase cardiometabolic disease risk but are difficult to disentangle. This study aimed to test the hypothesis that 4-10 years after a pregnancy complicated by overweight/obesity and GDM (OB-GDM), women and children would have greater adiposity and poorer cardiometabolic health than those with overweight/obesity (OB) or normal weight (NW) and no GDM during the index pregnancy.METHODS: In this cross-sectional study, mother-child dyads were stratified into three groups based on maternal health status during pregnancy (OB-GDM = 67; OB = 76; NW = 76). Weight, height, waist and hip circumferences, and blood pressure were measured, along with fasting glucose, insulin, HbA1c, lipids, adipokines, and cytokines.RESULTS: Women in the OB and OB-GDM groups had greater current adiposity and poorer cardiometabolic health outcomes than those in the NW group (p < 0.05). After adjusting for current adiposity, women in the OB-GDM group had higher HbA1c, glucose, HOMA-IR and triglycerides than NW and OB groups (p < 0.05). Among children, adiposity was greater in the OB-GDM versus NW group (p < 0.05), but other indices of cardiometabolic health did not differ.CONCLUSIONS: Poor cardiometabolic health in women with prior GDM is independent of current adiposity. Although greater adiposity among children exposed to GDM is evident at 4-10 years, differences in cardiometabolic health may not emerge until later.
KW - adiposity
KW - metabolic health
KW - pregnancy
KW - intrauterine programming
KW - diabetes
UR - http://www.scopus.com/inward/record.url?scp=85124729801&partnerID=8YFLogxK
M3 - Article
C2 - 36238222
SN - 2055-2238
VL - 8
SP - 627
EP - 640
JO - Obesity Science & Practice
JF - Obesity Science & Practice
IS - 5
ER -
