More than the genes, the tumor microenvironment in neuroblastoma

Lucia Borriello, Robert C. Seeger, Shahab Asgharzadeh, Yves A. DeClerck

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations

Abstract

Neuroblastoma is the second most common solid tumor in children. Since the seminal discovery of the role of amplification of the MYCN oncogene in the pathogenesis of neuroblastoma in the 1980s, much focus has been on the contribution of genetic alterations in the progression of this cancer. However it is now clear that not only genetic events play a role but that the tumor microenvironment (TME) substantially contributes to the biology of neuroblastoma. In this article, we present a comprehensive review of the literature on the contribution of the TME to the ten hallmarks of cancer in neuroblastoma and discuss the mechanisms of communication between neuroblastoma cells and the TME that underlie the influence of the TME on neuroblastoma progression. We end our review by discussing how the knowledge acquired over the last two decades in this field is now leading to new clinical trials targeting the TME.

Original languageEnglish
Pages (from-to)304-314
Number of pages11
JournalCancer Letters
Volume380
Issue number1
DOIs
StatePublished - Sep 1 2016

Keywords

  • Animals
  • Biomarkers, Tumor/genetics
  • Cell Communication
  • Cell Movement
  • Cell Proliferation
  • Cell Survival
  • Disease Progression
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Neuroblastoma/genetics
  • Signal Transduction
  • Tumor Microenvironment

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