Molecular Biology and Evolution of Cancer: From Discovery to Action

Jason A. Somarelli; Heather Gardner; Vincent L. Cannataro; Ella F. Gunady; Amy M. Boddy; Norman A. Johnson; Jeffrey Nicholas Fisk; Stephen G. Gaffney; Jeffrey H. Chuang; Sheng Li; Francesca D. Ciccarelli; Anna R. Panchenko; Kate Megquier; Sudhir Kumar; Alex Dornburg; James Degregori; Jeffrey P. Townsend

doi:10.1093/molbev/msz242

Molecular Biology and Evolution of Cancer: From Discovery to Action

Jason A. Somarelli
, Heather Gardner
, Vincent L. Cannataro
, Ella F. Gunady
, Amy M. Boddy
, Norman A. Johnson
, Jeffrey Nicholas Fisk
, Stephen G. Gaffney
, Jeffrey H. Chuang
, Sheng Li
, Francesca D. Ciccarelli
, Anna R. Panchenko
, Kate Megquier
, Sudhir Kumar
, Alex Dornburg
, James Degregori
, Jeffrey P. Townsend

Nuclear Dynamics and Cancer (NDC)

Duke University
Tufts University
Emmanuel College
University of California at Santa Barbara
University of Massachusetts
Yale University
Jackson Laboratory
The Francis Crick Institute
King's College London
Queen's University Kingston
Ontario Institute for Cancer Research
Massachusetts Institute of Technology
Temple University
North Carolina State Museum of Natural Sciences
University of Colorado Anschutz Medical Campus

Research output: Contribution to journal › Article › peer-review

56 Scopus citations

Abstract

Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution - and progression - require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

Original language	English
Pages (from-to)	320-326
Number of pages	7
Journal	Molecular Biology and Evolution
Volume	37
Issue number	2
DOIs	https://doi.org/10.1093/molbev/msz242
State	Published - Feb 1 2020

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Disease Progression
Evolution, Molecular
Genetic Fitness
Genomics/methods
Humans
Neoplasms/genetics
Phylogeny
Stem Cell Niche

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10.1093/molbev/msz242

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Somarelli, J. A., Gardner, H., Cannataro, V. L., Gunady, E. F., Boddy, A. M., Johnson, N. A., Fisk, J. N., Gaffney, S. G., Chuang, J. H., Li, S., Ciccarelli, F. D., Panchenko, A. R., Megquier, K., Kumar, S., Dornburg, A., Degregori, J., & Townsend, J. P. (2020). Molecular Biology and Evolution of Cancer: From Discovery to Action. Molecular Biology and Evolution, 37(2), 320-326. https://doi.org/10.1093/molbev/msz242

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title = "Molecular Biology and Evolution of Cancer: From Discovery to Action",

abstract = "Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution - and progression - require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.",

keywords = "Disease Progression, Evolution, Molecular, Genetic Fitness, Genomics/methods, Humans, Neoplasms/genetics, Phylogeny, Stem Cell Niche",

author = "Somarelli, \{Jason A.\} and Heather Gardner and Cannataro, \{Vincent L.\} and Gunady, \{Ella F.\} and Boddy, \{Amy M.\} and Johnson, \{Norman A.\} and Fisk, \{Jeffrey Nicholas\} and Gaffney, \{Stephen G.\} and Chuang, \{Jeffrey H.\} and Sheng Li and Ciccarelli, \{Francesca D.\} and Panchenko, \{Anna R.\} and Kate Megquier and Sudhir Kumar and Alex Dornburg and James Degregori and Townsend, \{Jeffrey P.\}",

note = "{\textcopyright} The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.",

year = "2020",

month = feb,

day = "1",

doi = "10.1093/molbev/msz242",

language = "English",

volume = "37",

pages = "320--326",

journal = "Molecular Biology and Evolution",

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}

Somarelli, JA, Gardner, H, Cannataro, VL, Gunady, EF, Boddy, AM, Johnson, NA, Fisk, JN, Gaffney, SG, Chuang, JH, Li, S, Ciccarelli, FD, Panchenko, AR, Megquier, K, Kumar, S, Dornburg, A, Degregori, J & Townsend, JP 2020, 'Molecular Biology and Evolution of Cancer: From Discovery to Action', Molecular Biology and Evolution, vol. 37, no. 2, pp. 320-326. https://doi.org/10.1093/molbev/msz242

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T1 - Molecular Biology and Evolution of Cancer

T2 - From Discovery to Action

AU - Somarelli, Jason A.

AU - Gardner, Heather

AU - Cannataro, Vincent L.

AU - Gunady, Ella F.

AU - Boddy, Amy M.

AU - Johnson, Norman A.

AU - Fisk, Jeffrey Nicholas

AU - Gaffney, Stephen G.

AU - Chuang, Jeffrey H.

AU - Li, Sheng

AU - Ciccarelli, Francesca D.

AU - Panchenko, Anna R.

AU - Megquier, Kate

AU - Kumar, Sudhir

AU - Dornburg, Alex

AU - Degregori, James

AU - Townsend, Jeffrey P.

N1 - © The Author(s) 2019. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

PY - 2020/2/1

Y1 - 2020/2/1

N2 - Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution - and progression - require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

AB - Cancer progression is an evolutionary process. During this process, evolving cancer cell populations encounter restrictive ecological niches within the body, such as the primary tumor, circulatory system, and diverse metastatic sites. Efforts to prevent or delay cancer evolution - and progression - require a deep understanding of the underlying molecular evolutionary processes. Herein we discuss a suite of concepts and tools from evolutionary and ecological theory that can inform cancer biology in new and meaningful ways. We also highlight current challenges to applying these concepts, and propose ways in which incorporating these concepts could identify new therapeutic modes and vulnerabilities in cancer.

KW - Disease Progression

KW - Evolution, Molecular

KW - Genetic Fitness

KW - Genomics/methods

KW - Humans

KW - Neoplasms/genetics

KW - Phylogeny

KW - Stem Cell Niche

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DO - 10.1093/molbev/msz242

M3 - Article

C2 - 31642480

AN - SCOPUS:85078868077

SN - 0737-4038

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SP - 320

EP - 326

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

IS - 2

ER -

Molecular Biology and Evolution of Cancer: From Discovery to Action

Abstract

UN SDGs

Keywords

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