Molecular and immunohistochemical detection of kaposi sarcoma herpesvirus/human herpesvirus-8

Amy Chadburn, Janet Wilson, Y. Lynn Wang

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

7 Scopus citations

Abstract

Kaposi sarcoma herpesvirus/human herpesvirus-8 (KSHV/HHV-8) is etiologically related to the development of several human diseases, including Kaposi sarcoma, primary effusion lymphoma (PEL)/extra-cavitary (EC) PEL, multicentric Castleman disease (MCD), and large B-cell lymphoma arising in KSHV/HHV-8-associated multicentric Castleman disease. Although serologic studies can identify persons infected with this virus, molecular genetics, specifically PCR (polymerase chain reaction) and immunohistochemical techniques, are rapid, sensitive, and specific, and are able to more closely link KSHV/HHV-8 to a given disease process. As these KSHV/HHV-8-related diseases cause significant morbidity and mortality in affected individuals, the identification of the virus within lesional tissue will allow for more targeted therapy.

Original languageEnglish
Title of host publicationHematological Malignancies
PublisherHumana Press Inc.
Pages245-256
Number of pages12
Volume999
ISBN (Print)9781627033565
DOIs
StatePublished - 2013

Publication series

NameMethods in Molecular Biology
Volume999
ISSN (Print)1064-3745

Keywords

  • Human herpesvirus-8
  • Immuno-histochemistry (IHC)
  • Kaposi sarcoma herpesvirus
  • LANA/LNA-1
  • ORF73
  • ORFK9-3
  • Polymerase chain reaction

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