Mitochondrial regulation of cell death: A phylogenetically conserved control

Lorenzo Galluzzi; Oliver Kepp; Guido Kroemer

doi:10.15698/mic2016.03.483

Mitochondrial regulation of cell death: A phylogenetically conserved control

Lorenzo Galluzzi, Oliver Kepp, Guido Kroemer

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.

Original language	English
Pages (from-to)	101-108
Number of pages	8
Journal	Microbial Cell
Volume	3
Issue number	3
DOIs	https://doi.org/10.15698/mic2016.03.483
State	Published - Mar 2016
Externally published	Yes

Keywords

Apoptosis
Autophagy
Autosis
Ferroptosis
MTP-driven regulated necrosis
Necroptosis
Parthanatos
Pyroptosis

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10.15698/mic2016.03.483

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abstract = "Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.",

keywords = "Apoptosis, Autophagy, Autosis, Ferroptosis, MTP-driven regulated necrosis, Necroptosis, Parthanatos, Pyroptosis",

author = "Lorenzo Galluzzi and Oliver Kepp and Guido Kroemer",

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year = "2016",

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AU - Kroemer, Guido

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AB - Mitochondria are fundamental for eukaryotic cells as they participate in critical catabolic and anabolic pathways. Moreover, mitochondria play a key role in the signal transduction cascades that precipitate many (but not all) regulated variants of cellular demise. In this short review, we discuss the differential implication of mitochondria in the major forms of regulated cell death.

KW - Apoptosis

KW - Autophagy

KW - Autosis

KW - Ferroptosis

KW - MTP-driven regulated necrosis

KW - Necroptosis

KW - Parthanatos

KW - Pyroptosis

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M3 - Article

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JO - Microbial Cell

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ER -

Mitochondrial regulation of cell death: A phylogenetically conserved control

Abstract

Keywords

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