Mitochondrial control of innate immune signaling by irradiated cancer cells

Takahiro Yamazaki; Lorenzo Galluzzi

doi:10.1080/2162402X.2020.1797292

Mitochondrial control of innate immune signaling by irradiated cancer cells

Takahiro Yamazaki, Lorenzo Galluzzi

Research output: Contribution to journal › Editorial

25 Scopus citations

Abstract

Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.

Original language	English
Article number	1797292
Journal	Oncoimmunology
Volume	9
Issue number	1
DOIs	https://doi.org/10.1080/2162402X.2020.1797292
State	Published - Jan 1 2020
Externally published	Yes

Keywords

Abscopal responses
autophagy
caspases
immunogenic cell death
micronuclei
STING
venetoclax

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/2162402X.2020.1797292

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title = "Mitochondrial control of innate immune signaling by irradiated cancer cells",

abstract = "Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.",

keywords = "Abscopal responses, autophagy, caspases, immunogenic cell death, micronuclei, STING, venetoclax",

author = "Takahiro Yamazaki and Lorenzo Galluzzi",

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AU - Yamazaki, Takahiro

AU - Galluzzi, Lorenzo

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N2 - Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.

AB - Type I interferon (IFN) release by irradiated cancer cells is paramount for radiation therapy to elicit anticancer immunity. Our findings demonstrate that mitochondrial outer membrane permeabilization (MOMP) triggered by RT enables exposure of mitochondrial DNA to the cytosol, hence setting off CGAS-driven type I IFN synthesis. These data point to the existence of a therapeutically actionable mitochondrial checkpoint that restricts innate immune signaling in irradiated cancer cells.

KW - Abscopal responses

KW - autophagy

KW - caspases

KW - immunogenic cell death

KW - micronuclei

KW - STING

KW - venetoclax

UR - http://www.scopus.com/inward/record.url?scp=85088435517&partnerID=8YFLogxK

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DO - 10.1080/2162402X.2020.1797292

M3 - Editorial

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JO - Oncoimmunology

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M1 - 1797292

ER -

Mitochondrial control of innate immune signaling by irradiated cancer cells

Abstract

Keywords

UN SDGs

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