Mitochondria in Cell Death Regulation

I. Vitale; G. Manic; G. Kroemer; L. Galluzzi

doi:10.1016/B978-0-12-394447-4.30046-3

Mitochondria in Cell Death Regulation

I. Vitale, G. Manic, G. Kroemer, L. Galluzzi

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

2 Scopus citations

Abstract

Besides producing the majority of intracellular adenosine triphosphate and participating in many anabolic circuitries that are required for the survival of eukaryotic cells, mitochondria play a central role in various signaling pathways that actively provoke cell death, including distinct forms of apoptosis and regulated necrosis. Here, we discuss the lethal mechanisms activated by mitochondria in response to adverse conditions or developmental cues, placing special emphasis on the signal transduction cascades that control the cell fate at mitochondrial membranes.

Original language	English
Title of host publication	Functional Cell Biology
Publisher	Elsevier Inc.
Pages	341-353
Number of pages	13
Volume	3
ISBN (Electronic)	9780123944474
ISBN (Print)	9780123947963
DOIs	https://doi.org/10.1016/B978-0-12-394447-4.30046-3
State	Published - 2016
Externally published	Yes

Keywords

AIF
Apoptosome
BAX
BCL-2
BID
Caspases
Cytochrome c
FF-ATPase
Mitochondrial outer membrane permeabilization
Mitochondrial permeability transition
Mitochondrial transmembrane potential
Necroptosis
PARP1
Parthanatos
Reactive oxygen species

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10.1016/B978-0-12-394447-4.30046-3

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title = "Mitochondria in Cell Death Regulation",

abstract = "Besides producing the majority of intracellular adenosine triphosphate and participating in many anabolic circuitries that are required for the survival of eukaryotic cells, mitochondria play a central role in various signaling pathways that actively provoke cell death, including distinct forms of apoptosis and regulated necrosis. Here, we discuss the lethal mechanisms activated by mitochondria in response to adverse conditions or developmental cues, placing special emphasis on the signal transduction cascades that control the cell fate at mitochondrial membranes.",

keywords = "AIF, Apoptosome, BAX, BCL-2, BID, Caspases, Cytochrome c, FF-ATPase, Mitochondrial outer membrane permeabilization, Mitochondrial permeability transition, Mitochondrial transmembrane potential, Necroptosis, PARP1, Parthanatos, Reactive oxygen species",

author = "I. Vitale and G. Manic and G. Kroemer and L. Galluzzi",

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doi = "10.1016/B978-0-12-394447-4.30046-3",

language = "English",

isbn = "9780123947963",

volume = "3",

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booktitle = "Functional Cell Biology",

publisher = "Elsevier Inc.",

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TY - CHAP

T1 - Mitochondria in Cell Death Regulation

AU - Vitale, I.

AU - Manic, G.

AU - Kroemer, G.

AU - Galluzzi, L.

PY - 2016

Y1 - 2016

N2 - Besides producing the majority of intracellular adenosine triphosphate and participating in many anabolic circuitries that are required for the survival of eukaryotic cells, mitochondria play a central role in various signaling pathways that actively provoke cell death, including distinct forms of apoptosis and regulated necrosis. Here, we discuss the lethal mechanisms activated by mitochondria in response to adverse conditions or developmental cues, placing special emphasis on the signal transduction cascades that control the cell fate at mitochondrial membranes.

AB - Besides producing the majority of intracellular adenosine triphosphate and participating in many anabolic circuitries that are required for the survival of eukaryotic cells, mitochondria play a central role in various signaling pathways that actively provoke cell death, including distinct forms of apoptosis and regulated necrosis. Here, we discuss the lethal mechanisms activated by mitochondria in response to adverse conditions or developmental cues, placing special emphasis on the signal transduction cascades that control the cell fate at mitochondrial membranes.

KW - AIF

KW - Apoptosome

KW - BAX

KW - BCL-2

KW - BID

KW - Caspases

KW - Cytochrome c

KW - FF-ATPase

KW - Mitochondrial outer membrane permeabilization

KW - Mitochondrial permeability transition

KW - Mitochondrial transmembrane potential

KW - Necroptosis

KW - PARP1

KW - Parthanatos

KW - Reactive oxygen species

UR - http://www.scopus.com/inward/record.url?scp=85025131433&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-394447-4.30046-3

DO - 10.1016/B978-0-12-394447-4.30046-3

M3 - Chapter

AN - SCOPUS:85025131433

SN - 9780123947963

VL - 3

SP - 341

EP - 353

BT - Functional Cell Biology

PB - Elsevier Inc.

ER -

Mitochondria in Cell Death Regulation

Abstract

Keywords

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