TY - JOUR
T1 - 'Microgranular' acute promyelocytic leukemia
T2 - A distinct clinical, ultrastructural, and cytogenetic entity
AU - Golomb, H. M.
AU - Rowley, J. D.
AU - Vardiman, J. W.
AU - Testa, J. R.
AU - Butler, A.
PY - 1980
Y1 - 1980
N2 - Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality [t 15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. However, the average granule sizes were 120, 170, and 180 nm, respectively, for the three patients, significantly less than the 250-nm resolution of light microscopy. We regard the leukemia in these three patients as comprising a distinct clinical, ultrastructural, and cytogenetic entity that we have chosen to call 'microgranular' acute promyelocytic leukemia.
AB - Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality [t 15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. However, the average granule sizes were 120, 170, and 180 nm, respectively, for the three patients, significantly less than the 250-nm resolution of light microscopy. We regard the leukemia in these three patients as comprising a distinct clinical, ultrastructural, and cytogenetic entity that we have chosen to call 'microgranular' acute promyelocytic leukemia.
KW - Adult
KW - Cytoplasmic Granules/ultrastructure
KW - Disseminated Intravascular Coagulation/complications
KW - Endoplasmic Reticulum/ultrastructure
KW - Female
KW - Humans
KW - Karyotyping
KW - Leukemia, Myeloid, Acute/diagnosis
KW - Metaphase
KW - Translocation, Genetic
UR - http://www.scopus.com/inward/record.url?scp=0018864144&partnerID=8YFLogxK
U2 - 10.1182/blood.v55.2.253.bloodjournal552253
DO - 10.1182/blood.v55.2.253.bloodjournal552253
M3 - Article
C2 - 6928105
AN - SCOPUS:0018864144
SN - 0006-4971
VL - 55
SP - 253
EP - 259
JO - Blood
JF - Blood
IS - 2
ER -