'Microgranular' acute promyelocytic leukemia: A distinct clinical, ultrastructural, and cytogenetic entity

H. M. Golomb, J. D. Rowley, J. W. Vardiman, J. R. Testa, A. Butler

Research output: Contribution to journalArticlepeer-review

166 Scopus citations

Abstract

Three patients with acute leukemia, disseminated intravascular coagulation, and a specific acquired chromosome abnormality [t 15;17)] were found by transmission electron microscopy to have the typical distribution of granules seen in promyelocytes. However, the average granule sizes were 120, 170, and 180 nm, respectively, for the three patients, significantly less than the 250-nm resolution of light microscopy. We regard the leukemia in these three patients as comprising a distinct clinical, ultrastructural, and cytogenetic entity that we have chosen to call 'microgranular' acute promyelocytic leukemia.

Original languageEnglish
Pages (from-to)253-259
Number of pages7
JournalBlood
Volume55
Issue number2
DOIs
StatePublished - 1980

Keywords

  • Adult
  • Cytoplasmic Granules/ultrastructure
  • Disseminated Intravascular Coagulation/complications
  • Endoplasmic Reticulum/ultrastructure
  • Female
  • Humans
  • Karyotyping
  • Leukemia, Myeloid, Acute/diagnosis
  • Metaphase
  • Translocation, Genetic

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