TY - JOUR
T1 - MHC-I genotype drives early immune selection of oncogenic mutations
AU - Marty, Rachel
AU - de Prisco, Nicola
AU - Carter, Hannah
AU - Font-Burgada, Joan
N1 - Publisher Copyright:
© 2018, © 2018 The Author(s). Published with license by Taylor & Francis Group, LLC. © 2018, © Rachel Marty, Nicola de Prisco, Hannah Carter and Joan Font-Burgada.
PY - 2018/3/4
Y1 - 2018/3/4
N2 - MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.
AB - MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.
KW - antigen presentation
KW - cancer
KW - cancer predisposition
KW - cancer susceptibility prediction
KW - human leukocyte antigen
KW - immunology, immunoediting
KW - immunotherapy
KW - major histocompatibility complex
KW - neoantigens
UR - http://www.scopus.com/inward/record.url?scp=85050744699&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000432934600003&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1080/23723556.2017.1409863
DO - 10.1080/23723556.2017.1409863
M3 - Article
C2 - 29487895
SN - 2372-3556
VL - 5
SP - e1409863
JO - Molecular and Cellular Oncology
JF - Molecular and Cellular Oncology
IS - 2
M1 - e1409863
ER -
