MHC-I genotype drives early immune selection of oncogenic mutations

Rachel Marty, Nicola de Prisco, Hannah Carter, Joan Font-Burgada

Research output: Contribution to journalArticlepeer-review

4 Scopus citations

Abstract

MHC-I exposes the intracellular contents to immune cells for surveillance of cellular health. Due to high genomic variation, individuals' immune systems differ in their ability to expose and eliminate cancer-causing mutations. These personalized immune blind spots create specific oncogenic mutation predispositions within patients and influence their prevalence across populations.

Original languageEnglish
Article numbere1409863
JournalMolecular and Cellular Oncology
Volume5
Issue number2
DOIs
StatePublished - Mar 4 2018

Keywords

  • antigen presentation
  • cancer
  • cancer predisposition
  • cancer susceptibility prediction
  • human leukocyte antigen
  • immunology, immunoediting
  • immunotherapy
  • major histocompatibility complex
  • neoantigens

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