Abstract
Disrupting mitochondrial function in malignant cells is a promising strategy to enhance anticancer immunity. We have recently demonstrated that depriving colorectal cancer cells of serine results in mitochondrial dysfunction coupled with the cytosolic accumulation of mitochondrial DNA and consequent activation of CGAS- and STING-dependent tumor-targeting immune responses.
| Original language | English |
|---|---|
| Article number | 2394247 |
| Journal | Oncoimmunology |
| Volume | 13 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2024 |
| Externally published | Yes |
Keywords
- Apoptotic caspases
- BCL2
- immune checkpoint inhibition
- MOMP
- senescence
- type I interferon
- DNA, Mitochondrial/metabolism
- Nucleotidyltransferases/genetics
- Mitochondria/metabolism
- Humans
- Membrane Proteins/genetics
- Colorectal Neoplasms/immunology
- Animals
