Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”

Ying Shao, Valeria Chernaya, Candice Johnson, William Y. Yang, Ramon Cueto, Xiaojin Sha, Yi Zhang, Xuebin Qin, Jianxin Sun, Eric T. Choi, Hong Wang, Xiao feng Yang

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: (1) Histone enzymes are differentially expressed in cardiovascular, immune, and other tissues; (2) our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, and histone methylation/demethylation are in the highest varieties; and (3) histone enzymes are more downregulated than upregulated in metabolic diseases and regulatory T cell (Treg) polarization/ differentiation, but not in tumors. These results have demonstrated a new working model of “Sand out and Gold stays,” where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.

Original languageEnglish
Pages (from-to)49-66
Number of pages18
JournalJournal of Cardiovascular Translational Research
Volume9
Issue number1
DOIs
StatePublished - Feb 1 2016
Externally publishedYes

Keywords

  • Epigenetic regulation
  • Gene expression and inflammation
  • Histone modification enzymes
  • Metabolic diseases
  • Regulatory T cell

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