TY - JOUR
T1 - Metabolic Diseases Downregulate the Majority of Histone Modification Enzymes, Making a Few Upregulated Enzymes Novel Therapeutic Targets—“Sand Out and Gold Stays”
AU - Shao, Ying
AU - Chernaya, Valeria
AU - Johnson, Candice
AU - Yang, William Y.
AU - Cueto, Ramon
AU - Sha, Xiaojin
AU - Zhang, Yi
AU - Qin, Xuebin
AU - Sun, Jianxin
AU - Choi, Eric T.
AU - Wang, Hong
AU - Yang, Xiao feng
N1 - Publisher Copyright:
© 2016, Springer Science+Business Media New York.
PY - 2016/2/1
Y1 - 2016/2/1
N2 - To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: (1) Histone enzymes are differentially expressed in cardiovascular, immune, and other tissues; (2) our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, and histone methylation/demethylation are in the highest varieties; and (3) histone enzymes are more downregulated than upregulated in metabolic diseases and regulatory T cell (Treg) polarization/ differentiation, but not in tumors. These results have demonstrated a new working model of “Sand out and Gold stays,” where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.
AB - To determine whether the expression of histone modification enzymes is regulated in physiological and pathological conditions, we took an experimental database mining approach pioneered in our labs to determine a panoramic expression profile of 164 enzymes in 19 human and 17 murine tissues. We have made the following significant findings: (1) Histone enzymes are differentially expressed in cardiovascular, immune, and other tissues; (2) our new pyramid model showed that heart and T cells are among a few tissues in which histone acetylation/deacetylation, and histone methylation/demethylation are in the highest varieties; and (3) histone enzymes are more downregulated than upregulated in metabolic diseases and regulatory T cell (Treg) polarization/ differentiation, but not in tumors. These results have demonstrated a new working model of “Sand out and Gold stays,” where more downregulation than upregulation of histone enzymes in metabolic diseases makes a few upregulated enzymes the potential novel therapeutic targets in metabolic diseases and Treg activity.
KW - Epigenetic regulation
KW - Gene expression and inflammation
KW - Histone modification enzymes
KW - Metabolic diseases
KW - Regulatory T cell
UR - http://www.scopus.com/inward/record.url?scp=84959093793&partnerID=8YFLogxK
U2 - 10.1007/s12265-015-9664-y
DO - 10.1007/s12265-015-9664-y
M3 - Article
C2 - 26746407
AN - SCOPUS:84959093793
SN - 1937-5387
VL - 9
SP - 49
EP - 66
JO - Journal of Cardiovascular Translational Research
JF - Journal of Cardiovascular Translational Research
IS - 1
ER -