TY - JOUR
T1 - Meta-analysis and pooled analysis of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers
T2 - A HuGE-GSEC review
AU - Varela-Lema, Leonor
AU - Taioli, Emanuela
AU - Ruano-Ravina, Alberto
AU - Barros-Dios, Juan M.
AU - Anantharaman, Devasena
AU - Benhamou, Simone
AU - Boccia, Stefania
AU - Bhisey, Rajani A.
AU - Cadoni, Gabriella
AU - Capoluongo, Ettore
AU - Chen, Chien Jen
AU - Foulkes, William D.
AU - Goloni-Bertollo, Eny Maria
AU - Hatagima, Ana
AU - Hayes, Richard B.
AU - Katoh, Takahiko
AU - Koifman, Sergio
AU - Lazarus, Phillip
AU - Manni, Johannes J.
AU - Mahimkar, Manoj
AU - Morita, Shunji
AU - Park, Jong
AU - Park, Kwang Kyun
AU - Pavarino Bertelli, Erika Cristina
AU - De Souza Fonseca Ribeiro, Enilze Maria
AU - Roy, Bidyut
AU - Spitz, Margaret R.
AU - Strange, Richard C.
AU - Wei, Qingyi
AU - Ragin, Camille C.
PY - 2008/6
Y1 - 2008/6
N2 - The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
AB - The association of GSTM1 and CYP1A1 polymorphisms and oral and pharyngeal cancers was assessed through a meta-analysis of published case-control studies and a pooled analysis of both published and unpublished case-control studies from the Genetic Susceptibility to Environmental Carcinogens database (http://www.upci.upmc.edu/research/ccps/ccontrol/index.html). Thirty publications used in the meta-analysis included a total of 7783 subjects (3177 cases and 4606 controls); 21 datasets, 9397 subjects (3130 cases and 6267 controls) were included in the pooled analysis. The GSTM1 deletion was 2-fold more likely to occur in African American and African cases than controls (odds ratio: 1.7, 95% confidence interval: 0.9-3.3), although this was not observed among whites (odds ratio: 1.0, 95% confidence interval: 0.9-1.1). The meta-analysis and pooled analysis showed a significant association between oral and pharyngeal cancer and the CYP1A1 MspI homozygous variant (meta-ORm2/m2: 1.9, 95% confidence interval: 1.4-2.7; Pooled ORm2m2: 2.0, 95% confidence interval: 1.3-3.1; ORm1m2 or [infi]m2m2: 1.3, 95% confidence interval: 1.1-1.6). The association was present for the CYP1A1 (exon 7) polymorphism (ORVal/Val: 2.2, 95% confidence interval: 1.1-4.5) in ever smokers. A joint effect was observed for GSTM1 homozygous deletion and the CYP1A1 m1m2 variant on cancer risk. Our findings suggest that tobacco use and genetic factors play a significant role in oral and pharyngeal cancer.
KW - Alleles
KW - Case-Control Studies
KW - Cytochrome P-450 CYP1A1/genetics
KW - Exons
KW - Genetic Predisposition to Disease
KW - Glutathione Transferase/genetics
KW - Homozygote
KW - Humans
KW - Mouth Neoplasms/ethnology
KW - Odds Ratio
KW - Pharyngeal Neoplasms/ethnology
KW - Polymorphism, Genetic
KW - Tobacco Use Disorder/complications
UR - http://www.scopus.com/inward/record.url?scp=48849104791&partnerID=8YFLogxK
UR - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=purepublist2023&SrcAuth=WosAPI&KeyUT=WOS:000256959900001&DestLinkType=FullRecord&DestApp=WOS
U2 - 10.1097/GIM.0b013e3181770196
DO - 10.1097/GIM.0b013e3181770196
M3 - Review article
C2 - 18496222
SN - 1098-3600
VL - 10
SP - 369
EP - 384
JO - Genetics in Medicine
JF - Genetics in Medicine
IS - 6
ER -
