Medulloblastoma cells resemble neuronal progenitors in their differentiation

Duancheng Guo; Yanghui Qu; Yijun Yang; Zeng Jie Yang

doi:10.1080/23723556.2020.1810514

Medulloblastoma cells resemble neuronal progenitors in their differentiation

Duancheng Guo, Yanghui Qu, Yijun Yang, Zeng Jie Yang

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.

Original language	English
Article number	1810514
Pages (from-to)	1810514
Journal	Molecular and Cellular Oncology
Volume	7
Issue number	6
DOIs	https://doi.org/10.1080/23723556.2020.1810514
State	Published - Nov 1 2020

Keywords

EZH2
Medulloblastoma
NeuroD1
differentiation
hedgehog pathway

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1080/23723556.2020.1810514

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title = "Medulloblastoma cells resemble neuronal progenitors in their differentiation",

abstract = "Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.",

keywords = "EZH2, Medulloblastoma, NeuroD1, differentiation, hedgehog pathway",

author = "Duancheng Guo and Yanghui Qu and Yijun Yang and Yang, {Zeng Jie}",

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AU - Guo, Duancheng

AU - Qu, Yanghui

AU - Yang, Yijun

AU - Yang, Zeng Jie

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Y1 - 2020/11/1

N2 - Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.

AB - Medulloblastoma (MB) often originate from cerebellar granule neuron precursors (GNPs). We recently found that medulloblastoma cells undergo differentiation as GNPs. Differentiated MB cells have permanently lost their proliferative capacity and tumorigenicity. The differentiation of MB cells is driven by the transcription factor NeuroD1 (Neurogenic differentiation 1), and NeuroD1 expression in MB cells is repressed by EZH2-mediated H3K27me3.

KW - EZH2

KW - Medulloblastoma

KW - NeuroD1

KW - differentiation

KW - hedgehog pathway

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Medulloblastoma cells resemble neuronal progenitors in their differentiation

Abstract

Keywords

UN SDGs

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