Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer

Robert G. Uzzo; Naomi B. Haas; Paul L. Crispen; Vladimir M. Kolenko

doi:10.1002/cncr.23318

Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer

Robert G. Uzzo, Naomi B. Haas, Paul L. Crispen, Vladimir M. Kolenko

Fox Chase Cancer Center

Research output: Contribution to journal › Review article › peer-review

24 Scopus citations

Abstract

New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.

Original language	English
Pages (from-to)	1660-1671
Number of pages	12
Journal	Cancer
Volume	112
Issue number	8
DOIs	https://doi.org/10.1002/cncr.23318
State	Published - Apr 15 2008

Keywords

Apoptosis
Cancer
Hormone refractory
Prostate
Treatment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/cncr.23318

Cite this

@article{e1dc6249f1a4449ba2a63d60a95f6878,

title = "Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer",

abstract = "New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.",

keywords = "Apoptosis, Cancer, Hormone refractory, Prostate, Treatment",

author = "Uzzo, {Robert G.} and Haas, {Naomi B.} and Crispen, {Paul L.} and Kolenko, {Vladimir M.}",

year = "2008",

month = apr,

day = "15",

doi = "10.1002/cncr.23318",

language = "English",

volume = "112",

pages = "1660--1671",

journal = "Cancer",

issn = "0008-543X",

publisher = "John Wiley and Sons Inc.",

number = "8",

}

TY - JOUR

T1 - Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer

AU - Uzzo, Robert G.

AU - Haas, Naomi B.

AU - Crispen, Paul L.

AU - Kolenko, Vladimir M.

PY - 2008/4/15

Y1 - 2008/4/15

N2 - New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.

AB - New therapeutic strategies are needed to improve treatment outcomes in men with hormone-refractory prostate cancer. A better understanding of the molecular mechanisms of cell death in response to therapeutic strategies will help avoid ineffective treatment regimens and provide a molecular basis for new therapeutic modalities targeting apoptosis-resistant forms of prostate cancer. In this review, the authors focused on the established aberrations of apoptosis in hormone-refractory prostate cancer, and they have described novel treatment strategies to overcome apoptosis resistance.

KW - Apoptosis

KW - Cancer

KW - Hormone refractory

KW - Prostate

KW - Treatment

UR - http://www.scopus.com/inward/record.url?scp=42149088906&partnerID=8YFLogxK

U2 - 10.1002/cncr.23318

DO - 10.1002/cncr.23318

M3 - Review article

C2 - 18278811

SN - 0008-543X

VL - 112

SP - 1660

EP - 1671

JO - Cancer

JF - Cancer

IS - 8

ER -

Mechanisms of apoptosis resistance and treatment strategies to overcome them in hormone-refractory prostate cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this