Mechanisms in homocysteine-induced vascular disease

Hong Wang; Hongmei Tan; Fan Yang

doi:10.1016/j.ddmec.2005.05.029

Mechanisms in homocysteine-induced vascular disease

Hong Wang
, Hongmei Tan
, Fan Yang

Baylor College of Medicine

Research output: Contribution to journal › Review article › peer-review

30 Scopus citations

Abstract

Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD). It has been reported that lowering plasma homocysteine (Hcy) levels improved endothelial dysfunction and reduced the incidence of major adverse events after percutaneous coronary intervention. We and others have provided experimental evidence supporting the hypothesis that Hcy is a causative factor for atherosclerosis. This article will discuss biological and molecular events related to cardiovascular pathological changes associated with HHcy.

Original language	English
Pages (from-to)	25-31
Number of pages	7
Journal	Drug Discovery Today: Disease Mechanisms
Volume	2
Issue number	1
DOIs	https://doi.org/10.1016/j.ddmec.2005.05.029
State	Published - 2005
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1016/j.ddmec.2005.05.029

Cite this

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title = "Mechanisms in homocysteine-induced vascular disease",

abstract = "Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD). It has been reported that lowering plasma homocysteine (Hcy) levels improved endothelial dysfunction and reduced the incidence of major adverse events after percutaneous coronary intervention. We and others have provided experimental evidence supporting the hypothesis that Hcy is a causative factor for atherosclerosis. This article will discuss biological and molecular events related to cardiovascular pathological changes associated with HHcy.",

author = "Hong Wang and Hongmei Tan and Fan Yang",

year = "2005",

doi = "10.1016/j.ddmec.2005.05.029",

language = "English",

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T1 - Mechanisms in homocysteine-induced vascular disease

AU - Wang, Hong

AU - Tan, Hongmei

AU - Yang, Fan

PY - 2005

Y1 - 2005

N2 - Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD). It has been reported that lowering plasma homocysteine (Hcy) levels improved endothelial dysfunction and reduced the incidence of major adverse events after percutaneous coronary intervention. We and others have provided experimental evidence supporting the hypothesis that Hcy is a causative factor for atherosclerosis. This article will discuss biological and molecular events related to cardiovascular pathological changes associated with HHcy.

AB - Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD). It has been reported that lowering plasma homocysteine (Hcy) levels improved endothelial dysfunction and reduced the incidence of major adverse events after percutaneous coronary intervention. We and others have provided experimental evidence supporting the hypothesis that Hcy is a causative factor for atherosclerosis. This article will discuss biological and molecular events related to cardiovascular pathological changes associated with HHcy.

UR - https://www.scopus.com/pages/publications/29244434326

U2 - 10.1016/j.ddmec.2005.05.029

DO - 10.1016/j.ddmec.2005.05.029

M3 - Review article

AN - SCOPUS:29244434326

SN - 1740-6765

VL - 2

SP - 25

EP - 31

JO - Drug Discovery Today: Disease Mechanisms

JF - Drug Discovery Today: Disease Mechanisms

IS - 1

ER -

Mechanisms in homocysteine-induced vascular disease

Abstract

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