Mechanisms in homocysteine-induced vascular disease

Hong Wang, Hongmei Tan, Fan Yang

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Hyperhomocysteinemia (HHcy) is a significant and independent risk factor for cardiovascular disease (CVD). It has been reported that lowering plasma homocysteine (Hcy) levels improved endothelial dysfunction and reduced the incidence of major adverse events after percutaneous coronary intervention. We and others have provided experimental evidence supporting the hypothesis that Hcy is a causative factor for atherosclerosis. This article will discuss biological and molecular events related to cardiovascular pathological changes associated with HHcy.

Original languageEnglish
Pages (from-to)25-31
Number of pages7
JournalDrug Discovery Today: Disease Mechanisms
Volume2
Issue number1
DOIs
StatePublished - 2005
Externally publishedYes

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