MDSCs sneak CSCs out of (immuno)surveillance

Carlos Jiménez-Cortegana; Claudia Galassi; Lorenzo Galluzzi

doi:10.1016/j.it.2021.11.008

MDSCs sneak CSCs out of (immuno)surveillance

Carlos Jiménez-Cortegana
, Claudia Galassi
, Lorenzo Galluzzi

Cornell University
University of Seville
Hospital Universitario Virgen Macarena

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of myeloid-derived suppressor cells.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Trends in Immunology
Volume	43
Issue number	1
DOIs	https://doi.org/10.1016/j.it.2021.11.008
State	Published - Jan 2022
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

gemcitabine
GM-CSF
immune checkpoint inhibitors
intracellular pH
MAPK signaling
NF-κB
Myeloid-Derived Suppressor Cells
Humans
Neoplastic Stem Cells
Aldehyde Dehydrogenase
Neoplasms

Access to Document

10.1016/j.it.2021.11.008

Cite this

@article{06654a7013ac46d589001dee44f9c1e5,

title = "MDSCs sneak CSCs out of (immuno)surveillance",

abstract = "Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of myeloid-derived suppressor cells.",

keywords = "gemcitabine, GM-CSF, immune checkpoint inhibitors, intracellular pH, MAPK signaling, NF-κB, Myeloid-Derived Suppressor Cells, Humans, Neoplastic Stem Cells, Aldehyde Dehydrogenase, Neoplasms",

author = "Carlos Jim{\'e}nez-Cortegana and Claudia Galassi and Lorenzo Galluzzi",

year = "2022",

month = jan,

doi = "10.1016/j.it.2021.11.008",

language = "English",

volume = "43",

pages = "1--3",

journal = "Trends in Immunology",

issn = "1471-4906",

publisher = "Elsevier Ltd.",

number = "1",

}

TY - JOUR

T1 - MDSCs sneak CSCs out of (immuno)surveillance

AU - Jiménez-Cortegana, Carlos

AU - Galassi, Claudia

AU - Galluzzi, Lorenzo

PY - 2022/1

Y1 - 2022/1

N2 - Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of myeloid-derived suppressor cells.

AB - Cancer stem cells (CSCs) are known for their superior tumor-initiating and tumor-repopulating potential, partly reflecting their pronounced ability to evade immune recognition. Liu and colleagues recently identified a new aldehyde dehydrogenase (ALDH)-dependent mechanism whereby triple-negative breast CSCs evade immunosurveillance upon recruitment of myeloid-derived suppressor cells.

KW - gemcitabine

KW - GM-CSF

KW - immune checkpoint inhibitors

KW - intracellular pH

KW - MAPK signaling

KW - NF-κB

KW - Myeloid-Derived Suppressor Cells

KW - Humans

KW - Neoplastic Stem Cells

KW - Aldehyde Dehydrogenase

KW - Neoplasms

UR - https://www.scopus.com/pages/publications/85120493810

U2 - 10.1016/j.it.2021.11.008

DO - 10.1016/j.it.2021.11.008

M3 - Article

C2 - 34863632

AN - SCOPUS:85120493810

SN - 1471-4906

VL - 43

SP - 1

EP - 3

JO - Trends in Immunology

JF - Trends in Immunology

IS - 1

ER -

MDSCs sneak CSCs out of (immuno)surveillance

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Fingerprint

Cite this