TY - JOUR
T1 - Maximizing resources to study an uncommon cancer
T2 - E2C2-Epidemiology of Endometrial Cancer Consortium
AU - Olson, Sara H.
AU - Chen, Chu
AU - De Vivo, Immaculata
AU - Doherty, Jennifer A.
AU - Hartmuller, Virginia
AU - Horn-Ross, Pamela L.
AU - Lacey, James V.
AU - Lynch, Shannon M.
AU - Sansbury, Leah
AU - Setiawan, V. Wendy
AU - Schouten, Leo J.
AU - Shu, Xiao Ou
PY - 2009/4
Y1 - 2009/4
N2 - Endometrial cancer affects more than 40,000 women a year in the U.S. While the association of this disease with high body mass index and sex steroid hormones is well known, there are many questions about etiology that have not been resolved. Little is known about the genetic basis for risk associated with hormones or obesity, other common genetic factors associated with risk, or gene-environment interactions. E2C2, the Epidemiology of Endometrial Cancer Consortium, was formed in 2006 to provide a collaborative environment for addressing these questions by pooling data from existing studies. This allows for investigations of uncommon risk factors, risk for rare histologic subtypes, and associations within strata that cannot be achieved in individual studies. This report describes the establishment of the consortium, ongoing projects that demonstrate the advantages of collaborative efforts, and challenges faced. Overall, the consortium promises to provide an important means of furthering our knowledge about this cancer.
AB - Endometrial cancer affects more than 40,000 women a year in the U.S. While the association of this disease with high body mass index and sex steroid hormones is well known, there are many questions about etiology that have not been resolved. Little is known about the genetic basis for risk associated with hormones or obesity, other common genetic factors associated with risk, or gene-environment interactions. E2C2, the Epidemiology of Endometrial Cancer Consortium, was formed in 2006 to provide a collaborative environment for addressing these questions by pooling data from existing studies. This allows for investigations of uncommon risk factors, risk for rare histologic subtypes, and associations within strata that cannot be achieved in individual studies. This report describes the establishment of the consortium, ongoing projects that demonstrate the advantages of collaborative efforts, and challenges faced. Overall, the consortium promises to provide an important means of furthering our knowledge about this cancer.
KW - Australia
KW - Case-Control Studies
KW - China
KW - Cohort Studies
KW - Endometrial Neoplasms/epidemiology
KW - Europe
KW - Female
KW - Health Resources/economics
KW - Humans
KW - International Cooperation
KW - Internet
KW - National Cancer Institute (U.S.)
KW - Risk Factors
KW - United States
UR - http://www.scopus.com/inward/record.url?scp=64649096479&partnerID=8YFLogxK
U2 - 10.1007/s10552-008-9290-y
DO - 10.1007/s10552-008-9290-y
M3 - Article
C2 - 19132539
AN - SCOPUS:64649096479
SN - 0957-5243
VL - 20
SP - 491
EP - 496
JO - Cancer Causes and Control
JF - Cancer Causes and Control
IS - 4
ER -
