Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer

Naiyu Chen; Colleen B McGrath; Caroline I Ericsson; Jane B Vaselkiv; Emily M Rencsok; Konrad H Stopsack; Hannah E Guard; Karen A Autio; Dana E Rathkopf; Deborah Enting; Rhonda L Bitting; Joaquin Mateo; Charles Waihenya Githiaka; Kim N Chi; Heather H Cheng; Ian D Davis; Simon G Anderson; Simone Ann Marie Badal; Anders Bjartell; Kjell M Russnes; Elisabeth I Heath; Mark M Pomerantz; John C Henegan; Terry Hyslop; Emilio Esteban; Aurelius Omlin; Ray McDermott; Andre P Fay; Ademola Alabi Popoola; Camille Ragin; Joel Nowak; Travis Gerke; Philip W Kantoff; Daniel J George; Kathryn L Penney; Lorelei A Mucci

doi:10.1158/1055-9965.EPI-23-1207

Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer

Naiyu Chen, Colleen B McGrath, Caroline I Ericsson, Jane B Vaselkiv, Emily M Rencsok, Konrad H Stopsack, Hannah E Guard, Karen A Autio, Dana E Rathkopf, Deborah Enting, Rhonda L Bitting, Joaquin Mateo, Charles Waihenya Githiaka, Kim N Chi, Heather H Cheng, Ian D Davis, Simon G Anderson, Simone Ann Marie Badal, Anders Bjartell, Kjell M RussnesElisabeth I Heath, Mark M Pomerantz, John C Henegan, Terry Hyslop, Emilio Esteban, Aurelius Omlin, Ray McDermott, Andre P Fay, Ademola Alabi Popoola, Camille Ragin, Joel Nowak, Travis Gerke, Philip W Kantoff, Daniel J George, Kathryn L Penney, Lorelei A Mucci

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).

METHODS: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).

RESULTS: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).

CONCLUSIONS: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.

IMPACT: This research highlighted the importance of social support in OS within this vulnerable population.

Original language	English
Pages (from-to)	419-425
Number of pages	7
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	33
Issue number	3
DOIs	https://doi.org/10.1158/1055-9965.EPI-23-1207
State	E-pub ahead of print - Dec 8 2024

Keywords

Aged
Europe
Humans
Male
Marital Status
Prostatic Neoplasms, Castration-Resistant
Registries
Social Support

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1158/1055-9965.EPI-23-1207

Cite this

Chen, N., McGrath, C. B., Ericsson, C. I., Vaselkiv, J. B., Rencsok, E. M., Stopsack, K. H., Guard, H. E., Autio, K. A., Rathkopf, D. E., Enting, D., Bitting, R. L., Mateo, J., Githiaka, C. W., Chi, K. N., Cheng, H. H., Davis, I. D., Anderson, S. G., Badal, S. A. M., Bjartell, A., ... Mucci, L. A. (2024). Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer. Cancer Epidemiology Biomarkers and Prevention, 33(3), 419-425. Advance online publication. https://doi.org/10.1158/1055-9965.EPI-23-1207

@article{64aaa29ac8834480ad3a28baed560228,

title = "Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer",

abstract = "BACKGROUND: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).METHODS: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).RESULTS: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).CONCLUSIONS: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.IMPACT: This research highlighted the importance of social support in OS within this vulnerable population.",

keywords = "Aged, Europe, Humans, Male, Marital Status, Prostatic Neoplasms, Castration-Resistant, Registries, Social Support",

author = "Naiyu Chen and McGrath, {Colleen B} and Ericsson, {Caroline I} and Vaselkiv, {Jane B} and Rencsok, {Emily M} and Stopsack, {Konrad H} and Guard, {Hannah E} and Autio, {Karen A} and Rathkopf, {Dana E} and Deborah Enting and Bitting, {Rhonda L} and Joaquin Mateo and Githiaka, {Charles Waihenya} and Chi, {Kim N} and Cheng, {Heather H} and Davis, {Ian D} and Anderson, {Simon G} and Badal, {Simone Ann Marie} and Anders Bjartell and Russnes, {Kjell M} and Heath, {Elisabeth I} and Pomerantz, {Mark M} and Henegan, {John C} and Terry Hyslop and Emilio Esteban and Aurelius Omlin and Ray McDermott and Fay, {Andre P} and Popoola, {Ademola Alabi} and Camille Ragin and Joel Nowak and Travis Gerke and Kantoff, {Philip W} and George, {Daniel J} and Penney, {Kathryn L} and Mucci, {Lorelei A}",

note = "{\textcopyright}2024 American Association for Cancer Research.",

year = "2024",

month = dec,

day = "8",

doi = "10.1158/1055-9965.EPI-23-1207",

language = "English",

volume = "33",

pages = "419--425",

journal = "Cancer Epidemiology Biomarkers and Prevention",

issn = "1055-9965",

publisher = "American Association for Cancer Research Inc.",

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Chen, N, McGrath, CB, Ericsson, CI, Vaselkiv, JB, Rencsok, EM, Stopsack, KH, Guard, HE, Autio, KA, Rathkopf, DE, Enting, D, Bitting, RL, Mateo, J, Githiaka, CW, Chi, KN, Cheng, HH, Davis, ID, Anderson, SG, Badal, SAM, Bjartell, A, Russnes, KM, Heath, EI, Pomerantz, MM, Henegan, JC, Hyslop, T, Esteban, E, Omlin, A, McDermott, R, Fay, AP, Popoola, AA, Ragin, C, Nowak, J, Gerke, T, Kantoff, PW, George, DJ, Penney, KL & Mucci, LA 2024, 'Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 33, no. 3, pp. 419-425. https://doi.org/10.1158/1055-9965.EPI-23-1207

Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer. / Chen, Naiyu; McGrath, Colleen B; Ericsson, Caroline I et al.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 33, No. 3, 08.12.2024, p. 419-425.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer

AU - Chen, Naiyu

AU - McGrath, Colleen B

AU - Ericsson, Caroline I

AU - Vaselkiv, Jane B

AU - Rencsok, Emily M

AU - Stopsack, Konrad H

AU - Guard, Hannah E

AU - Autio, Karen A

AU - Rathkopf, Dana E

AU - Enting, Deborah

AU - Bitting, Rhonda L

AU - Mateo, Joaquin

AU - Githiaka, Charles Waihenya

AU - Chi, Kim N

AU - Cheng, Heather H

AU - Davis, Ian D

AU - Anderson, Simon G

AU - Badal, Simone Ann Marie

AU - Bjartell, Anders

AU - Russnes, Kjell M

AU - Heath, Elisabeth I

AU - Pomerantz, Mark M

AU - Henegan, John C

AU - Hyslop, Terry

AU - Esteban, Emilio

AU - Omlin, Aurelius

AU - McDermott, Ray

AU - Fay, Andre P

AU - Popoola, Ademola Alabi

AU - Ragin, Camille

AU - Nowak, Joel

AU - Gerke, Travis

AU - Kantoff, Philip W

AU - George, Daniel J

AU - Penney, Kathryn L

AU - Mucci, Lorelei A

PY - 2024/12/8

Y1 - 2024/12/8

N2 - BACKGROUND: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).METHODS: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).RESULTS: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).CONCLUSIONS: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.IMPACT: This research highlighted the importance of social support in OS within this vulnerable population.

AB - BACKGROUND: Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).METHODS: IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).RESULTS: We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02-2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22-2.94).CONCLUSIONS: Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.IMPACT: This research highlighted the importance of social support in OS within this vulnerable population.

KW - Aged

KW - Europe

KW - Humans

KW - Male

KW - Marital Status

KW - Prostatic Neoplasms, Castration-Resistant

KW - Registries

KW - Social Support

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U2 - 10.1158/1055-9965.EPI-23-1207

DO - 10.1158/1055-9965.EPI-23-1207

M3 - Article

C2 - 38189661

SN - 1055-9965

VL - 33

SP - 419

EP - 425

JO - Cancer Epidemiology Biomarkers and Prevention

JF - Cancer Epidemiology Biomarkers and Prevention

IS - 3

ER -

Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer

Abstract

Keywords

UN SDGs

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Research from Harvard University T.H. Chan School of Public Health in the Area of Prostate Cancer Published (Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men ...)

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Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Press/Media

Research from Harvard University T.H. Chan School of Public Health in the Area of Prostate Cancer Published (Marital status, living arrangement, and survival among individuals with advanced prostate cancer in the International Registry for Men ...)

Cite this